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品种反应性 主要应用 宿主 格式 抗体类型 M IHC, ELISA, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB1921 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Integrin α5 Antibody Alternate Names - CD49e
产品信息 格式 Serum 演示 Whole rabbit serum. Liquid, with 0.02% sodium azide. 应用 应用 Detect Integrin α5 using this Anti-Integrin α5 Antibody validated for use in ELISA, WB, IH. 主要应用 - Immunohistochemistry
- ELISA
- Western Blotting
应用说明 ELISA.
Western blotting: (The antigen should be separated in SDS-PAGE under reducing conditions
and does not react with non-reduced sample.): 1:5,000.
Immunohistochemistry/Immunofluorescence: 1:1,000.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Recombinant fragment of mouse alpha5 integrin (Holers et al. 1989) corresponding to amino acid residues 655-880 of the human protein (Argraves 1987). This region of the molecule is extracellular and is included in the heavy chain (120 kDa). 宿主 Rabbit 特异性 Specific for alpha5 integrin as determined by Western blotting. 品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002205.2
Entrez基因汇总 The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. 基因符号 - FNRA
- ITGA5
- VLA-5
- CD49e
- VLA5A
UniProt编号 - P08648
UniProt汇总 FUNCTION: SwissProt: P08648 # Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 1049 amino acids; 114536 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P08648 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,MAB4197-KC,Mouse Anti-Human Topoisomerase IIα (Ki-S1) (KC)
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