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  • merck millipore,默克密理博,06-1374,Anti-phospho MRE11 (Thr636) Antibody

  • merck millipore,默克密理博,06-1374,Anti-phospho MRE11 (Thr636) Antibody

    产品名称：Anti-phospho MRE11 (Thr636) Antibody
    产品型号：06-1374
    Anti-phospho MRE11 (Thr636) Antibody is a rabbit polyclonal antibody for detection of phospho MRE11 (Thr636) also known as MRE11 meiotic recombination 11 homolog A (S. cerevisiae), has been validated  More>>

    merck millipore,默克密理博,06-1374,Anti-phospho MRE11 (Thr636) Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-1374,Anti-phospho MRE11 (Thr636) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-1374
    描述 Anti-phospho MRE11 (Thr636) Antibody
    Alternate Names
    • AT-like disease
    • MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
    • meiotic recombination (S. cerevisiae) 11 homolog A
    • double-strand break repair protein MRE11A
    • Meiotic recombination 11 homolog A
    • Meiotic recombination 11 homolog 1
    • DNA recombination and repair protein
    • MRE11 homolog 1
    • endo/exonuclease Mre11
    • MRE11 homolog A
    背景信息 MRE11 is is a nuclear protein involved the DNA damge repair and recombination. This protein is part of the MRN complex composed of three main components: Mre11, Rad50, and Nbs1/Xrs2. This protein complex is involved in signaling pathways that lead to both checkpoint activation and DNA repair. Mutations and defects in expression of this protein can lead to genomic instability, telomere shortening, aberrant meiosis and hypersensitivity to DNA damage.
    产品信息
    格式 Affinity Purified
    控制
    • Anisomycin untreated and treated HEK293 cell lysates
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-phospho MRE11 (Thr636) Antibody is a rabbit polyclonal antibody for detection of phospho MRE11 (Thr636) also known as MRE11 meiotic recombination 11 homolog A (S. cerevisiae), has been validated in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human MRE11 phosphorylated at Thr636.
    表位 Phosphorylated Thr636
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes MRE11 phosphorylated at Thr636.
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_005581
    Entrez基因汇总 This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq].
    基因符号
    • HNGS1
    • MRE11A
    • MRE11
    • MRE11B
    • ATLD
    修改
    • Phosphorylation
    纯化方法 Affinity purified
    UniProt编号
    • P49959
    UniProt汇总 FUNCTION: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

    COFACTOR: Manganese (By similarity).

    SUBUNIT STRUCTURE: Component of the MRN complex composed of two heterodimers RAD50/MRE11A associated with a single NBN. Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11A and NBN (By similarity). Interacts with DCLRE1C/Artemis and DCLRE1B/Apollo.

    SUBCELLULAR LOCATION: Nucleus (By similarity). Note: Localizes to discrete nuclear foci after treatment with genotoxic agents (By similarity).

    PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.

    INVOLVEMENT IN DISEASE: Defects in MRE11A are a cause of ataxia telangiectasia-like disorder (ATLD) [MIM:604391]. ATLD is a disease with the same clinical feature than ataxia-telangiectasia but with a somewhat milder clinical course.

    MISCELLANEOUS: In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells.

    SEQUENCE SIMILARITIES: Belongs to the MRE11/RAD32 family.
    产品使用声明
    质量保证 Evaluated by Western Blot in anisomycin untreated and treated HEK293 cell lysates.

    Western Blot Analysis: 1 µg/mL of this antibody detected MRE11 on 10 µg of anisomycin untreated and treated HEK293 cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,06-1374,Anti-phospho MRE11 (Thr636) Antibody

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