merck millipore,默克密理博,MABC187,Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132S Antibody, clone SMab-1

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB, ICC	M	Purified	Monoclonal Antibody

描述
产品目录编号	MABC187
描述	Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132S Antibody, clone SMab-1
Alternate Names	IDP NADP(+)-specific ICDH Oxalosuccinate decarboxylase Isocitrate dehydrogenase [NADP] cytoplasmic IDH Cytosolic NADP-isocitrate dehydrogenase
背景信息	Isocitrate dehydrogenase 1 (IDH1) is a 46 kDa NADP-dependent enzyme, which catalyzes the decarboxylation of isocitrate into α-ketoglutarate. IDH1 may also play a role in the prevention of oxidative damage, and the shuttling of proteins to peroxisomes. It is widely reported that mutations in IDH1 result in multiple forms of gliomas. The Arginine to Serine substitution at amino acid 132 is seen in gliomas, abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.

产品信息
格式	Purified
控制	S8 overexpressing CHO cell lysate
演示	Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132S Antibody, clone SMab-1 is an antibody against Isocitrate Dehydrogenase 1 (IDH1)-R132S for use in Western Blotting, ICC & IHC.
主要应用	Immunohistochemistry Western Blotting Immunocytochemistry
应用说明	Western Blot Analysis: A 1:250 dilution from a representative lot detected Isocitrate Dehydrogenase 1 (IDH1)-R132S in a panel of CHO cell lysates expressing wild-type and mutated IDH1. Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Isocitrate Dehydrogenase 1 (IDH1)-R123S in gliblastoma tissues that express the IDH1-R132S mutation. Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Isocitrate Dehydrogenase 1 (IDH1)-R123S in IDH1-R132S-transfected LN229 cells.

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to human Isocitrate Dehydrogenase 1 (IDH1)-R132S.
克隆	Smab-1
宿主	Mouse
特异性	This antibody only detects the R132S mutation of Isocitrate Dehydrogenase (IDH1).
同种型	IgG1κ
品种反应性	Human
Species Reactivity Note	Demonstrated to react with Human.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_005887
基因符号	PICD IDH1
纯化方法	Protein G purified
UniProt编号	O75874

产品使用声明
质量保证	Evaluated by Western Blot in S8 overexpressing CHO cell lysate. Western Blot Analysis: A 1:2,000 dilution from a representative lot detected Isocitrate Dehydrogenase 1 (IDH1)-R132S in S8 overexpressing CHO cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µL

merck millipore,默克密理博,MABC187,Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132S Antibody, clone SMab-1

whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech