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品种反应性 主要应用 宿主 格式 抗体类型 M, H ICC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE573 描述 Anti-Zeb2 Antibody Alternate Names - Zinc finger homeobox protein 1b
- Zinc finger E-box-binding homeobox 2
- Smad-interacting protein 1
- SMADIP1
背景信息 Zinc finger E-box-binding homeobox 2 (Zeb2), also known as Smad-interacting protein 1 (SIP1, SMADIP1) and Zinc finger homeobox protein 1b (ZFHX1B, ZFX1B), is a transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters and interacts with activated SMADs. Zeb2 has been shown to repress the transcription of the E-cadherin gene and induce epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing in vitro. It is suggested that Zeb2 contributes to tumor progression since it’s been demonstrated to protect cells from DNA damage-induced apoptosis. Recent studies have shown that Zeb2 is often observed in the cytoplasm in numerous cancer tissues, implying that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Mowat-Wilson syndrome (MWIS), also known as Hirschsprung disease-mental syndrome. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Zeb2 is an antibody against Zeb2 for use in WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected Zeb2 in A375 cells. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of Human Zeb2. 表位 C-terminus 浓缩 Please refer to lot specific datasheet. 宿主 Rabbit 品种反应性 MouseHuman Species Reactivity Note Human, Mouse. Predicted to react with Rat based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_055610
基因符号 - HRIHFB2411
- ZEB2
- KIAA0569
- SIP1
- ZFHX1B
- ZFX1B
纯化方法 Antigen Affinity purified UniProt编号 - O60315
产品使用声明 质量保证 Evaluated by Western Blotting in a mouse embryonic stem cell lysate.
Western Blotting Analysis: A 0.2 µg/mL dilution of this antibody detected Zeb2 in a mouse embryonic stem cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,35675,β-Glycerophosphate, Disodium Salt, Pentahydrate - CAS 13408-09-8 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,MAB1612,Anti-Cytokeratin Epithelial Antibody, clone AE1
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