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merck millipore,默克密理博,MAB1612,Anti-Cytokeratin Epithelial Antibody, clone AE1
产品名称:Anti-Cytokeratin Epithelial Antibody, clone AE1
产品型号:MAB1612
This Anti-Cytokeratin Epithelial Antibody, clone AE1 is validated for use in IH(P) for the detection of Cytokeratin Epithelial.
merck millipore,默克密理博,MAB1612,Anti-Cytokeratin Epithelial Antibody, clone AE1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Rb, B, Ch, H, M, R IH(P) M Purified Monoclonal Antibody 描述 产品目录编号 MAB1612 Replaces 04-588 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Cytokeratin Epithelial Antibody, clone AE1 产品信息 格式 Purified 演示 Liquid in 0.05M Borate Buffered Saline, 0.15M NaCl, 0.09% Sodium Azide, pH8.2. 应用 应用 This Anti-Cytokeratin Epithelial Antibody, clone AE1 is validated for use in IH(P) for the detection of Cytokeratin Epithelial. 主要应用 - Immunohistochemistry (Paraffin)
应用说明 Immunohistochemistry on unfixed frozen sections and formalin-fixed paraffin embedded tissues. Antigen retrieval is recommended. HEIR or protease treatment can be used.
Western Blotting: AE1 recognizes LMW cytokeratins from the acidic subfamily including: Clone AE1 recognises the 56.5, 50, 50', 48 and 40kD human cytokeratins of the acidic subfamily.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Human epidermal keratin 克隆 AE1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Recognizes most of the acidic (Type I) keratins. It is broadly reactive and stains positively almost all epithelia and their neoplasms. MAB1612 produces heterogeneous staining within a given epithelium; the detailed staining pattern varies depending on the differentiated and/or growth state of individual cells. 同种型 IgG 品种反应性 RabbitBovineChickenHumanMouseRat 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002273.2
基因符号 - CARD2
- KRT8
- KO
- K8
- CYK8
- Keratin-8
- CK-8
- Cytokeratin-8
- K2C8
- CK8
UniProt编号 - P05787
UniProt汇总 FUNCTION: SwissProt: P05787 # Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
SIZE: 483 amino acids; 53704 Da
SUBUNIT: Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
DISEASE:SwissProt: P05787 # Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600].
SIMILARITY: SwissProt: P05787 ## Belongs to the intermediate filament family.
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months. 包装信息 数量 500 µg
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