merck millipore,默克密理愽
  • merck millipore,默克密理博,05-726,Anti-53BP1 Antibody, clone BP13

  • merck millipore,默克密理博,05-726,Anti-53BP1 Antibody, clone BP13

    产品名称：Anti-53BP1 Antibody, clone BP13
    产品型号：05-726
    Detect 53BP1 with Anti-53BP1 Antibody, clone BP13 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB, ICC.

    merck millipore,默克密理博,05-726,Anti-53BP1 Antibody, clone BP13

  • 产品介绍
  • merck millipore,默克密理博,05-726,Anti-53BP1 Antibody, clone BP13

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-726
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-53BP1 Antibody, clone BP13
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Detect 53BP1 with Anti-53BP1 Antibody, clone BP13 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Does not cross-react with mouse.
    生物信息
    免疫原品种 Mix of three GST fusion proteins corresponding to residues 1-337, 338-671, and 1331-1664, respectively, of human 53BP1
    克隆 clone BP13
    宿主 Mouse
    特异性 53BP1
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_005657.1
    基因符号
    • MGC138366
    • TP53BP1
    • 53BP1
    • p53BP1
    • p202
    • FLJ41424
    纯化方法 Protein G purfied
    UniProt编号
    • Q12888
    UniProt汇总 FUNCTION: SwissProt: Q12888 # May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage.
    SIZE: 1972 amino acids; 213574 Da
    SUBUNIT: Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H3 that has been methylated on 'Lys-79'. Does not bind unmethylated histone H3.
    SUBCELLULAR LOCATION: Nucleus. Kinetochore. Note=Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks.
    PTM: Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. & Phosphorylated in an ATM-dependent manner in response to DNA damage.
    SIMILARITY: SwissProt: Q12888 ## Contains 2 BRCT domains.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on lysates from HeLa cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-726,Anti-53BP1 Antibody, clone BP13

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下一件merck millipore产品：merck millipore,默克密理博,35675,β-Glycerophosphate, Disodium Salt, Pentahydrate - CAS 13408-09-8 - Calbiochem


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