merck millipore,默克密理愽
  • merck millipore,默克密理博,CC079,MMP-9, human, transfected cells (pro and active)

  • merck millipore,默克密理博,CC079,MMP-9, human, transfected cells (pro and active)

    产品名称：MMP-9, human, transfected cells (pro and active)
    产品型号：CC079


    merck millipore,默克密理博,CC079,MMP-9, human, transfected cells (pro and active)

  • 产品介绍
  • merck millipore,默克密理博,CC079,MMP-9, human, transfected cells (pro and active)

    重要规格表

    主要应用 Entrez基因编号 品种 Uni Prot编号
    PCNM_004994.2HumanP14780
    描述
    产品目录编号 CC079
    Replaces CC087
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 MMP-9, human, transfected cells (pro and active)
    Alternate Names
    • Gelatinase B
    产品信息
    演示 Purified protein in 5 mM Tris-HCl, pH 7.5, 0.1 mM CaCl2, containing 0.005% Brij 35.
    应用
    主要应用
    • Positive Control
    生物信息
    浓缩 0.1 mg/mL
    纯度 By SDS PAGE:

    Visual evaluation of bands for this lot:

    Minor band: MMP-9 Dimer ~ 180 kDa

    >85% MMP-9 Proenzyme ~ 88 kDa non-reduced, 92 kDa reduced

    0% Intermediate active form ~ 84 kDa non-reduced

    0% Mature active form ~ 82 kDa non-reduced

    10% TIMP ~ 28 kDa

    0% Extraneous bands

    By Gelatinase Zymography:

    Significant bands are visible for the proenzyme and activation products only.

    CONTAMINANT(S):

    None identified.
    品种 Human
    Entrez基因编号
    • NM_004994.2
    Entrez基因汇总 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
    基因符号
    • 82 kDa matrix metalloproteinase-9].
    • MMP9
    • MMP-9
    • GELB
    • CLG4B
    • EC 3.4.24.35 [Contains: 67 kDa matrix metalloproteinase-9
    UniProt编号
    • P14780
    UniProt汇总 FUNCTION: SwissProt: P14780 # May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond.
    COFACTOR: Binds 2 zinc ions per subunit. & Binds 3 calcium ions per subunit.
    SIZE: 707 amino acids; 78427 Da
    SUBUNIT: Exists as monomer, disulfide-linked homodimer, and as a heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form.
    TISSUE SPECIFICITY: Produced by normal alveolar macrophages and granulocytes.
    DOMAIN: SwissProt: P14780 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    PTM: Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
    SIMILARITY: Belongs to the peptidase M10A family. & Contains 3 fibronectin type-II domains. & Contains 4 hemopexin-like domains.
    MISCELLANEOUS: In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -70°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 10 µg

    merck millipore,默克密理博,CC079,MMP-9, human, transfected cells (pro and active)

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