merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB4418,Anti-Achaete Scute homolog 2 Antibody, clone 7E2

  • merck millipore,默克密理博,MAB4418,Anti-Achaete Scute homolog 2 Antibody, clone 7E2

    产品名称：Anti-Achaete Scute homolog 2 Antibody, clone 7E2
    产品型号：MAB4418
    Anti-Achaete Scute homolog 2 Antibody, clone 7E2 detects level of Achaete Scute homolog 2 & has been published & validated for use in WB, IC, ChIP.

    merck millipore,默克密理博,MAB4418,Anti-Achaete Scute homolog 2 Antibody, clone 7E2

  • 产品介绍
  • merck millipore,默克密理博,MAB4418,Anti-Achaete Scute homolog 2 Antibody, clone 7E2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HChIP, WB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB4418
    描述 Anti-Achaete Scute homolog 2 Antibody, clone 7E2
    Alternate Names
    • mammalian achaete/scute homologue 2
    • achaete-scute complex (Drosophila) homolog-like 2
    • achaete-scute complex homolog 2 (Drosophila)
    • achaete-scute complex homolog-like 2
    • achaete-scute complex-like 2
    • achaete-scute complex-like 2 (Drosophila)
    背景信息 Achaete Scute homolog 2 (also known as mammalian aschaete-scute homolog 2 or Mash2) is a nuclear protein expressed specifically in the extravillous trophoblasts of developing placenta. Placental development involves control by the basic helix-loop-helix transcription factor Achaete Scute homolog 2, which may regulate HIF (hypoxia) in the formation of spongiotrophoblasts. Targeted mutagenesis of Achaete Scute homolog 2 yielded loss of function results in embryonic lethality at midgestation due to placental failure associated with a lack of spongiotrophoblasts and reduced labyrinthine trophoblast layers. In addition to healthy placental development, Achaete Scute proteins may also be involved in the determination of neuronal precursors in the central and peripheral nervous systems. Achaete Scute homolog 2 has also been implicated as a controller of intestinal stem cell fate and is essential for the maintenance of adult intestinal stem cells (Tanaka, M., et al., (1997) Dev Biol. 190(10):55-65).
    产品信息
    格式 Purified
    控制
    • Human placenta tissue lysate
    演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Anti-Achaete Scute homolog 2 Antibody, clone 7E2 detects level of Achaete Scute homolog 2 & has been published & validated for use in WB, IC, ChIP.
    主要应用
    • Chromatin Immunoprecipitation (ChIP)
    • Western Blotting
    • Immunocytochemistry
    应用说明 Immunocytochemmistry Analysis: A previous lot was used by an independent laboratory in IC (Van de Flier, L.G., et al., 2009)

    Chromatin Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in ChIP (Hatzis, P., et al., 2008).
    生物信息
    免疫原品种 His-tagged recombinant protein corresponding to human Achaete Scute homolog 2 near the C-terminus.
    表位 C-terminus
    克隆 7E2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes Achaete Scute homolog 2 near the C-terminus.
    同种型 IgG2bκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_005161.1
    Entrez基因汇总 This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq].
    基因符号
    • Mash2
    • ASCL2
    • ASH2
    • HASH2
    • MASH2
    纯化方法 Protein G purfied
    UniProt编号
    • Q99929
    UniProt汇总 FUNCTION: AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.

    SUBUNIT STRUCTURE: Efficient DNA binding requires dimerization with another bHLH protein.

    SUBCELLULAR LOCATION: Nucleus.

    TISSUE SPECIFICITY: Expressed specifically in the extravillous trophoblasts of the developing placenta.

    SEQUENCE SIMILARITIES: Contains 1 basic helix-loop-helix (bHLH) domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in human placenta tissue lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected Achaete Scute homolog 2 in 10 µg of human placenta tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB4418,Anti-Achaete Scute homolog 2 Antibody, clone 7E2

上一件merck millipore产品：merck millipore,默克密理博,MABN259,Anti-Axin-2 Antibody, clone 5H9.1
下一件merck millipore产品：merck millipore,默克密理博,475837,MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem


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