merck millipore,默克密理愽
  • merck millipore,默克密理博,475837,MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem

  • merck millipore,默克密理博,475837,MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem

    产品名称：MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem
    产品型号：475837
    The MIF Antagonist, ISO-1, also referenced under CAS 478336-92-4, controls the biological activity of MIF.

    merck millipore,默克密理博,475837,MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,475837,MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₂H₁₃NO₄478336-92-4
    描述
    概述 A cell-permeable isoxazoline compound that displays anti-inflammatory properties. Inhibits MIF tautomerase activity by binding to its catalytic active site (IC50 = 7 µM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes, and arachidonic acid in RAW 264.7 macrophages. Shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model. Also available as a 50 mM solution in DMSO (Cat. No. 505225).
    产品目录编号 475837
    品牌系列 Calbiochem®
    同义词 (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester, Macrophage Migration Inhibitory Factor Antagonist, ISO-1
    参考
    参考 Cvetkovic, I., et al. 2005. Endocrinology, 146, 2942.
    Lubetsky, J.B., et al. 2002. J. Biol. Chem. 277, 24976.
    产品信息
    CAS号 478336-92-4
    具有ATP竞争性 N
    形式 Light yellow solid
    Hill配方 C₁₂H₁₃NO₄
    化学配方 C₁₂H₁₃NO₄
    Molar Mass 235.1
    可逆 N
    结构配方图像
    生物信息
    主靶 MIF tautomerize
    主靶IC50 7 µM for D-dopachrome tautomerase
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,475837,MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,07-2146,Anti-ARHGAP30 Antibody


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