merck millipore,默克密理愽
  • merck millipore,默克密理博,521233,PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem

  • merck millipore,默克密理博,521233,PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem

    产品名称：PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem
    产品型号：521233


    merck millipore,默克密理博,521233,PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,521233,PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₆FN₃O₂627518-40-5
    描述
    概述 A cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC50 < 33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC50 = 4.2 nM and 45 nM for -β and -α, respectively) and c-Abl (IC50 = 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC50 = 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk's-1,-2,-4 &-7, bFGFR-1 and EGFR (IC50 = 3.1 µM, > 10 µM, > 10 µM, 45.8 µM and > 100 µM, respectively).
    产品目录编号 521233
    品牌系列 Calbiochem®
    同义词 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409
    参考
    参考 Ho, C.Y., et al. 2005. J. Med. Chem. 48, 8163.
    产品信息
    CAS号 627518-40-5
    具有ATP竞争性 Y
    形式 Off-white solid
    Hill配方 C₁₈H₁₆FN₃O₂
    化学配方 C₁₈H₁₆FN₃O₂
    Molar Mass 325.3
    可逆 Y
    结构配方图像
    生物信息
    主靶 PDGFR Tyrosine Kinase
    主靶IC50 4.2 nM and 45 nM for -β and -α form of PDGFR, respectively
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or MeOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,521233,PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem

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