- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC460 描述 Anti-Sec23B Antibody Alternate Names - Pancreatic carcinoma marker protein GA733-1
- Tumor-associated calcium signal transducer 2
- Cell surface glycoprotein Trop-2
- Membrane component chromosome 1 surface marker 1
背景信息 The protein named Sec23B, also known as protein transport protein Sec23B, or SEC23-related protein B is a component of the COPII coat, the complex that governs ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. The transport of proteins in eukaryotic cells from the endoplasmic reticulum (ER) to the Golgi complex proceeds by deformation of specialized portions of the donor membrane to form carrier vesicles. A group of cytosolic proteins collectively known as COPII carry out a programmed set of sequential interactions, leading to cargo sorting and vesicle budding. The Sec23B protein is critical to proper protein transport in and out of cells, and it is localized to the smooth endoplasmic reticulum membrane where it is a peripheral membrane protein and interacts with the Golgi apparatus membranes as well. Sec23B is expressed at high levels in brain and fibroblasts as well as liver and other metabolically active tissues. Defects in Sec23B cause congenital dyserythropoietic anemia type II, a recessive disorder of erythroid differentiation but the disease is not caused by loss of function of Sec23B but rather a combination of a hypomorphic allele with altered functionality appears to be the cause and its related protein Sec23A can often compensate somewhat for the defect. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect Sec23B using this rabbit polyclonal antibody, Anti-Sec23B Antibody validated for use in western blotting. 主要应用 - Western Blotting
应用说明 Western Blotting Analysis: A representative lot from an independent laboratory detected Sec23B in various mouse tissue lysates expressing wild-type Sec23B. The same lot detected Sec23B in Sec23B wild-type MEF cell lysates and demonstrated a loss of signal in Sec23B knockdown MEF cell lysates (Tao, J., et al. (2012). Proc Natl Acad Sci USA. 109(29):E2001-E2009.). 生物信息 免疫原品种 Linear peptide corresponding to mouse Sec23B. 宿主 Rabbit 品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001239472
基因符号 - TROP2
- TACSTD2
- GA733-1
- M1S1
纯化方法 Affinity Purified UniProt编号 - Q9D662
产品使用声明 质量保证 Evaluated by Western Blotting in mouse pancreas tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Sec23B in 10 µg of mouse pancreas tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,07-2146,Anti-ARHGAP30 Antibody
下一件merck millipore产品：merck millipore,默克密理博,231085,Cilostamide - CAS 68550-75-4 - Calbiochem
相关产品
merck millipore,默克密理博,FCMAB230P,Milli-Mark™ Mouse IgG1-k, clone MOPC-21, PE conjugate
merck millipore,默克密理博,MABN259,Anti-Axin-2 Antibody, clone 5H9.1
merck millipore,默克密理博,MAB4418,Anti-Achaete Scute homolog 2 Antibody, clone 7E2
merck millipore,默克密理博,475837,MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem
merck millipore,默克密理博,07-2146,Anti-ARHGAP30 Antibody
merck millipore,默克密理博,231085,Cilostamide - CAS 68550-75-4 - Calbiochem
merck millipore,默克密理博,CBL1300,Anti-VCAM-1 Antibody, clone M/K
merck millipore,默克密理博,ABF199,Anti-TIM-1 Antibody
merck millipore,默克密理博,344342,D-Fructose-6-phosphate, Disodium Salt - CAS 26177-86-6 - Calbiochem
merck millipore,默克密理博,MAB8043,Anti-Adenovirus 1,2,5,6 Antibody, clone 7/48.7c