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品种反应性 主要应用 宿主 格式 抗体类型 M IHC, FC R Purified Monoclonal Antibody 描述 产品目录编号 CBL1300 Replaces MAB2242 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-VCAM-1 Antibody, clone M/K Alternate Names - CD106
产品信息 格式 Purified 控制 - EOMA and BMS2 endothelial cell lysates
演示 The monoclonal is presented in phosphate buffered saline containing 10mM sodium azide. 应用 应用 Anti-VCAM-1 Antibody, clone M/K is an antibody against VCAM-1 for use in FC, IH & IP. 主要应用 - Immunohistochemistry
- Flow Cytometry
应用说明 Studies of cell-cell interaction
Cell adhesion assays
Inhibition of lymphopoieisis in Whitlock-Witte long-term marrow cultures
Immunoprecipitation of the VCAM-1 integrin complex
Detection of VCAM-1 cells by immunofluorescence and immunohistochemical staining: acetone or fresh frozen sections work best; although zinc formalin or PLP fixations are reported to work but they have not be verified by Chemicon.
Optimal working dilutions must be determined by the end user.生物信息 克隆 M/K - 2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 特异性 Recognizes Murine vascular adhesion molecule (VCAM-1), single chain glycoprotein of Mr 100- kDa (under reducing conditions). VCAM-1 is present on the +/+ 2.4 stromal cell clone, large cells in bone marrow, and a subset of thymic macrophages. The stromal cell antigen is also detectable on the EOMA and BMS2 endothelial cell lines. The antibody reacts with all known isoforms of murine VCAM-1. 同种型 IgG1κ 品种反应性 Mouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_080682.1
- NM_001078.2
Entrez基因汇总 This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. 基因符号 - L1CAM
- VCAM1
- INCAM-100
- MGC99561
- CD106
- DKFZp779G2333
纯化方法 Protein A purfied UniProt编号 - P19320
UniProt汇总 FUNCTION: SwissProt: P19320 # Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
SIZE: 739 amino acids; 81276 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
DOMAIN: SwissProt: P19320 Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
PTM: Sialoglycoprotein.
DISEASE:SwissProt: P19320 # May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.
SIMILARITY: Contains 7 Ig-like C2-type (immunoglobulin-like) domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C. 包装信息 数量 500 µg
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