merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB19292,Anti-ADAM2 Antibody, clone 9D2.2

  • merck millipore,默克密理博,MAB19292,Anti-ADAM2 Antibody, clone 9D2.2

    产品名称：Anti-ADAM2 Antibody, clone 9D2.2
    产品型号：MAB19292
    This Anti-ADAM2 Antibody, clone 9D2.2 is validated for use in ELISA, WB for the detection of ADAM2.

    merck millipore,默克密理博,MAB19292,Anti-ADAM2 Antibody, clone 9D2.2

  • 产品介绍
  • merck millipore,默克密理博,MAB19292,Anti-ADAM2 Antibody, clone 9D2.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MWB, ELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB19292
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-ADAM2 Antibody, clone 9D2.2
    Alternate Names
    • Fertilin beta
    产品信息
    格式 Purified
    演示 Liquid at 1 mg/mL in PBS containing 0.05% sodium azide.
    应用
    应用 This Anti-ADAM2 Antibody, clone 9D2.2 is validated for use in ELISA, WB for the detection of ADAM2.
    主要应用
    • Western Blotting
    • ELISA
    不建议的应用
    • Immunohistochemistry
    应用说明 Western blot: 1:500 - 1:1,000 dilution for detected against sperm lysates, using standard alkaline phosphatase with NBT/BCIP detection. Chemiluminescent detection may permit higher dilutions.

    Not effective for immunohistochemistry.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Recombinant mouse fertilin produced by baculovirus expressin in SF9 cells.
    克隆 9D2.2
    宿主 Mouse
    特异性 Recognizes mouse fertilin beta by immunoblot, staining of bands in a 46-48 kDa range (multiple bands are due to variable protein glycosylation).
    同种型 IgG2b
    品种反应性 Mouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001464.3
    Entrez基因汇总 This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.
    基因符号
    • CT15
    • ADAM2
    • PH30
    • CRYN1
    • FTNB
    • PH30-beta
    • CRYN2
    • PH-30b
    • PH-30
    UniProt编号
    • Q99965
    UniProt汇总 FUNCTION: SwissProt: Q99965 # Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
    SIZE: 735 amino acids; 82457 Da
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.
    DOMAIN:SwissProt: Q99965 A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
    PTM: The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.
    SIMILARITY: Contains 1 disintegrin domain. & Contains 1 EGF-like domain. & Contains 1 peptidase M12B domain.
    MISCELLANEOUS: In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin subunit alpha is a pseudogene.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB19292,Anti-ADAM2 Antibody, clone 9D2.2

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