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merck millipore,默克密理博,444285,MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem
产品名称：MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem
产品型号：444285
The MMP-2/MMP-9 Inhibitor V, also referenced under CAS 869577-53-7, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors application More>>
merck millipore,默克密理博,444285,MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₆H₁₇NO₅S₃ 869577-53-7 描述 概述 A cell-permeable sulfonamido analog of SB-3CT (Cat. No. 444274) that displays enhanced aqueous solubility and improved selectivity (Ki = 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively). Inhibits MMP-3, MMP-7, and MMP-1 only at much higher concentrations (Ki = 3.6 µM, 295 µM, and > 25 µM, respectively). Binds to the enzyme active site and acts as an irreversible inhibitor. Reported to potently suppress cell migration and invasion of HT1080 cells (80% inhibition at 2 µM and > 25% inhibition at 100 nM, respectively). Unlike the general MMP inhibitor GM6001 (Cat. No. 364205), this inhibitor does not block the activation of cellular pro-MMP-2 by MT1-MMP. 产品目录编号 444285 品牌系列 Calbiochem®
同义词 (4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methylthiirane, SB-3CT, pMS 参考 参考 Ikejiri, M., et al. 2005. J. Biol. Chem. 280, 33992. 产品信息 CAS号 869577-53-7 具有ATP竞争性 N 形式 White solid Hill配方 C₁₆H₁₇NO₅S₃ 化学配方 C₁₆H₁₇NO₅S₃ Molar Mass 399.5 可逆 N 结构配方图像 生物信息 主靶 MMP-2 主靶Ki 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively 纯度 ≥85% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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