merck millipore,默克密理愽
  • merck millipore,默克密理博,361554,GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem

  • merck millipore,默克密理博,361554,GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem

    产品名称：GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem
    产品型号：361554
    The GSK-3β Inhibitor XII, TWS119, also referenced under CAS 601514-19-6, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphoryla More>>

    merck millipore,默克密理博,361554,GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,361554,GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₄N₄O₂601514-19-6
    描述
    概述 A cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).
    产品目录编号 361554
    品牌系列 Calbiochem®
    同义词 Neurogenesis Inducer, TWS119
    参考
    参考 Ding, S., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7632.
    产品信息
    CAS号 601514-19-6
    具有ATP竞争性 N
    形式 Beige solid
    Hill配方 C₁₈H₁₄N₄O₂
    化学配方 C₁₈H₁₄N₄O₂
    Molar Mass 318.3
    可逆 N
    结构配方图像
    生物信息
    主靶 GSK-3β
    主靶IC50 30 nM; Kd = 126 nM against GSK-3β
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or MeOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,361554,GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,6410-OP,OmniPur Neutralization Solution - Calbiochem


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