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merck millipore,默克密理博,CBL266,Anti-Cytokeratin 1 Antibody, 10, clone LH1
产品名称：Anti-Cytokeratin 1 Antibody, 10, clone LH1
产品型号：CBL266
Detect Cytokeratin 1 using this Anti-Cytokeratin 1 Antibody, 10, clone LH1 validated for use in WB, IH.
merck millipore,默克密理博,CBL266,Anti-Cytokeratin 1 Antibody, 10, clone LH1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 CBL266 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Cytokeratin 1 Antibody, 10, clone LH1 产品信息 格式 Purified 演示 The monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 应用 Detect Cytokeratin 1 using this Anti-Cytokeratin 1 Antibody, 10, clone LH1 validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Western blotting.
IHC formalin fixed sections, HIER (Microwave citrate buffer pH6.0) produces some staining but pretreatment with type XXIV protease (0.5mg/ml) produces best results.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Keratin 1 and 10. 克隆 LH1 宿主 Mouse 特异性 This antibody reacts with the suprabasal cells of stratified squamous epithelia in human, murine and porcine species. 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_006121.3
Entrez基因汇总 This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. 基因符号 - KRTA
- KRT1
- CK-1
- EHK1
- Keratin-1
- Cytokeratin-1
- CK1
- KRT1A
- K1
UniProt编号 - P13645
- P04264
UniProt汇总 SIZE: 644 amino acids; 66018 Da
SUBUNIT: Heterotetramer of two type I and two type II keratins. keratin-1 is generally associated with keratin-10.
TISSUE SPECIFICITY: The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.
PTM: Undergoes deimination of some arginine residues (citrullination).
DISEASE: SwissProt: P04264 # Defects in KRT1 are a cause of epidermolytic hyperkeratosis (EHK) [MIM:113800]; also known as bullous congenital ichthyosiform erythroderma (BIE). EHK is a hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum. & Defects in KRT1 are the cause of Curth-Macklin type ichthyosis hystrix (IHCM) [MIM:146590]. & Defects in KRT1 are a cause of nonepidermolytic palmoplantar keratoderma (NEPPK) [MIM:600962]; also known as Unna- Thost disease. & Defects in KRT1 are a cause of annular epidermolytic ichthyosis (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI resembles clinical and histologic features of both epidermolytic hyperkeratosis and ichthyosis bullosa of Siemens. & Defects in KRT1 are the cause of keratosis palmoplantaris striata III (PPKS3) [MIM:607654]; also known as striate palmoplantar keratoderma III (SPPK3). PPKS3 is an autosomal dominant disorder affecting palm and sole skin where stratum corneum and epidermal layers are thickened. There is no involvement of non-palmoplantar skin, and both hair and nails are normal.
SIMILARITY: SwissProt: P04264 ## Belongs to the intermediate filament family.
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C. 包装信息 数量 100 µg
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