merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3312,Anti-MMP-3 Antibody, clone 148-1A3

  • merck millipore,默克密理博,MAB3312,Anti-MMP-3 Antibody, clone 148-1A3

    产品名称：Anti-MMP-3 Antibody, clone 148-1A3
    产品型号：MAB3312
    Anti-MMP-3 Antibody, clone 148-1A3 detects level of MMP-3 & has been published & validated for use in ELISA, WB, IH(P).

    merck millipore,默克密理博,MAB3312,Anti-MMP-3 Antibody, clone 148-1A3

  • 产品介绍
  • merck millipore,默克密理博,MAB3312,Anti-MMP-3 Antibody, clone 148-1A3

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RbWB, ELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB3312
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-MMP-3 Antibody, clone 148-1A3
    Alternate Names
    • Proteoglycanase
    • Stromelysin-1
    • Transin
    产品信息
    格式 Purified
    演示 Liquid in 0.1M Na-Phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin.
    应用
    应用 Anti-MMP-3 Antibody, clone 148-1A3 detects level of MMP-3 & has been published & validated for use in ELISA, WB, IH(P).
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Immunoblotting: 1:100-1:500 dilution, typically on concentrated cell supernatants or extracts.

    Immunohistochemistry on paraffin-embedded tissues: PLP fixation required. Fixation with traditional formalin fixation can be problematic.

    ElA: detection antibody
    生物信息
    克隆 148-1A3
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 The antibody specifically reacts with the precursor and active forms of rabbit MMP-3. This is a purified mouse monoclonal antibody to rabbit matrix metalloproteinase 3 (rabbit MMP-3, stromelysin-1) from rabbit uterine cervical fibroblasts.

    SPECIES REACTIVITY:

    Does not cross-react with mouse and rat MMP-3, respectively.
    同种型 IgG1κ
    品种反应性 Rabbit
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002422.3
    Entrez基因汇总 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
    基因符号
    • EC 3.4.24.17
    • MMP3
    • STR1
    • Transin-1
    • STMY
    • MGC126102
    • STMY1
    • SL-1
    • MGC126103
    • MGC126104
    • transin-1
    • proteoglycanase
    • MMP-3
    • progelatinase
    UniProt编号
    • P08254
    UniProt汇总 FUNCTION: SwissProt: P08254 # Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
    COFACTOR: Binds 4 calcium ions per subunit. & Binds 2 zinc ions per subunit.
    SIZE: 477 amino acids; 53977 Da
    DOMAIN: SwissProt: P08254 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains.
    产品使用声明
    销售限制 This product is not available for sale in Japan.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    • Manufactured by Daiichi Fine Chemical Co., Ltd
    储存和货运信息
    存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB3312,Anti-MMP-3 Antibody, clone 148-1A3

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