merck millipore,默克密理愽
  • merck millipore,默克密理博,05-374,Anti-Cyclin A Antibody, clone BF 683

  • merck millipore,默克密理博,05-374,Anti-Cyclin A Antibody, clone BF 683

    产品名称：Anti-Cyclin A Antibody, clone BF 683
    产品型号：05-374
    Anti-Cyclin A Antibody, clone BF 683 is a high quality Mouse Monoclonal Antibody for the detection of Cyclin A & has been validated in IP & WB.

    merck millipore,默克密理博,05-374,Anti-Cyclin A Antibody, clone BF 683

  • 产品介绍
  • merck millipore,默克密理博,05-374,Anti-Cyclin A Antibody, clone BF 683

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-374
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Cyclin A Antibody, clone BF 683
    产品信息
    格式 Purified
    演示 mouse monoclonal IgG1 containing 0.05% sodium azide
    应用
    应用 Anti-Cyclin A Antibody, clone BF 683 is a high quality Mouse Monoclonal Antibody for the detection of Cyclin A & has been validated in IP & WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Recombinant human Cyclin A1.
    克隆 clone BF 683
    宿主 Mouse
    特异性 Cyclin A
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001237
    Entrez基因汇总 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • Cyclin-A1.
    • CCNA1
    纯化方法 Protein G chromatography
    UniProt编号
    • P78396
    UniProt汇总 FUNCTION: SwissProt: P78396 # May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
    SIZE: 465 amino acids; 52358 Da
    SUBUNIT: Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with KLHDC9.
    TISSUE SPECIFICITY: Very high levels in testis and very low levels in brain. Also found in myeloid Leukemia cell lines.
    DEVELOPMENTAL STAGE: Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases.
    SIMILARITY: SwissProt: P78396 ## Belongs to the cyclin family. Cyclin AB subfamily.
    产品使用声明
    质量保证 routinely evaluated in immunoblot on HeLa nuclear extract, or human A431 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 250 µL

    merck millipore,默克密理博,05-374,Anti-Cyclin A Antibody, clone BF 683

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