merck millipore,默克密理愽
  • merck millipore,默克密理博,407331,ILK inhibitor, Cpd 22 - Calbiochem

  • merck millipore,默克密理博,407331,ILK inhibitor, Cpd 22 - Calbiochem

    产品名称：ILK inhibitor, Cpd 22 - Calbiochem
    产品型号：407331
    The ILK inhibitor, Cpd 22 controls the biological activity of ILK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,407331,ILK inhibitor, Cpd 22 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,407331,ILK inhibitor, Cpd 22 - Calbiochem

    重要规格表

    经验配方
    C₃₀H₃₀F₃N₅O
    描述
    概述 A cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC50 = 600 nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC50 = 1 to 2.5 µM) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model.
    产品目录编号 407331
    品牌系列 Calbiochem®
    同义词 N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)biphenyl-4-yl)-1H-pyrazol-3-yl)propanamide
    参考
    参考 Lee, S., et al. 2011. J. Med. Chem. 54, 6364
    产品信息
    形式 Off-white powder
    Hill配方 C₃₀H₃₀F₃N₅O
    化学配方 C₃₀H₃₀F₃N₅O
    Molar Mass 553.6
    结构配方图像
    生物信息
    纯度 ≥94% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,407331,ILK inhibitor, Cpd 22 - Calbiochem

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