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merck millipore,默克密理博,MAB1922Z,Anti-Laminin α2 Antibody, clone 5H2, Azide Free
产品名称：Anti-Laminin α2 Antibody, clone 5H2, Azide Free
产品型号：MAB1922Z
Anti-Laminin α2 Antibody, clone 5H2, Azide Free detects level of Laminin α2 & has been published & validated for use in ELISA, IH, IP & WB.
merck millipore,默克密理博,MAB1922Z,Anti-Laminin α2 Antibody, clone 5H2, Azide Free
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Rb, H, Mk WB, ELISA, IHC M Purified Monoclonal Antibody 描述 产品目录编号 MAB1922Z 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Laminin α2 Antibody, clone 5H2, Azide Free Alternate Names - MAB1922
- MerosinMchain
产品信息 格式 Purified 应用 应用 Anti-Laminin α2 Antibody, clone 5H2, Azide Free detects level of Laminin α2 & has been published & validated for use in ELISA, IH, IP & WB. 主要应用 - Western Blotting
- ELISA
- Immunohistochemistry
应用说明 ELISA: 50% maximal binding to human merosin at 1:50,000.
Immunohistochemistry: 1:5,000 for staining of 8 mm acetone-fixed cryostat muscle sections, prior to detection with a peroxidase-conjugated secondary antibody.
Immunofluorescence
Affinity chromatography
Immunoprecipitation
Immunoblotting
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Purified human merosin. 克隆 5H2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Reacts with the 80 kDa fragment of the M-chain of human merosin.
SPECIES REACTIVITIES:
Cross reacts with monkey and rabbit merosin.同种型 IgG1 品种反应性 RabbitHumanMonkey 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001079823.1
- NM_000426.3
Entrez基因汇总 Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. 基因符号 - LAMM
- LAMA2
UniProt编号 - P24043
UniProt汇总 FUNCTION: SwissProt: P24043 # Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
SIZE: 3110 amino acids; 342771 Da
SUBUNIT: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-2 is a subunit of laminin-2 (merosin) and laminin-4 (S- merosin).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
TISSUE SPECIFICITY: Placenta, striated muscle, peripheral nerve, cardiac muscle, pancreas, lung, spleen, kidney, adrenal gland, skin, testis, meninges, choroid plexus, and some other regions of the brain; not in liver, thymus and bone.
DOMAIN: SwissProt: P24043 The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. & Domains VI, IV and G are globular.
DISEASE: SwissProt: P24043 # Defects in LAMA2 are the cause of merosin-deficient congenital muscular dystrophy type 1A (MDC1A) [MIM:607855]. MDC1A is characterized by difficulty walking, hypotonia, proximal weakness, hyporeflexia, and white matter hypodensity on MRI.
SIMILARITY: Contains 17 laminin EGF-like domains. & Contains 5 laminin G-like domains. & Contains 2 laminin IV type A domains. & Contains 1 laminin N-terminal domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain between 2 and 8°C for up to 6 months. 包装信息 数量 100 µg
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