merck millipore,默克密理愽
  • merck millipore,默克密理博,217721,InSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem

  • merck millipore,默克密理博,217721,InSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem

    产品名称：InSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem
    产品型号：217721
    The InSolution™ Cdk1 Inhibitor IV, RO-3306 controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,217721,InSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,217721,InSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem

    重要规格表

    经验配方
    C₁₈H₁₃N₃OS₂
    描述
    概述 A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki =2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. The solid form of this compound (Cat. No. 217699) is also available.
    产品目录编号 217721
    品牌系列 Calbiochem®
    同义词 5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one, 5-(6-Quinolinylmethylene)-2-((2-thienylmethyl)amino)-4(5H)-thiazolone
    参考
    参考 Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660.
    产品信息
    形式 Liquid
    配方 A 10 mM (2 mg/569 µL) solution of Cdk1 Inhibitor IV, RO-3306 (Cat. No. 217699) in DMSO.
    Hill配方 C₁₈H₁₃N₃OS₂
    Molar Mass 351.5
    吸湿 Hygroscopic
    可逆 Y
    结构配方图像
    生物信息
    主靶 Cdk1/B1 and Cdk1/A
    主靶Ki 35 nM and 110 nM for Cdk1/B1 and Cdk1/A,
    副靶 Cdk2/E, PKCδ, and SGK
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    安全信息
    R相 R: 36/38

    Irritating to eyes and skin.
    S相 S: 26-36

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Irritant
    储存 ≤ -70°C
    避光 Protect from light
    吸湿 Hygroscopic
    避免冻结 / 解冻 Avoid freeze/thaw
    无需冷冻 No
    特殊指南 Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,217721,InSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem

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