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merck millipore,默克密理博,616451,TGF-β RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem
产品名称：TGF-β RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem
产品型号：616451
The TGF-β RI Kinase Inhibitor, also referenced under CAS 396129-53-6, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosp More>>
merck millipore,默克密理博,616451,TGF-β RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₇H₁₂N₄ 396129-53-6 描述 概述 A cell-permeable diheteroaryl-substituted pyrazole compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of TGF-β Receptor I kinase (IC50 = 51 nM). Displays ~15-fold greater selectivity over p38α MAP kinase (IC50 = 740 nM). Shown to inhibit TGF-β-dependent cellular growth (IC50 = 89 nM in NIH 3T3 mouse fibroblasts) and transcription activation (IC50 = 47 nM in mink lung cells). 产品目录编号 616451 品牌系列 Calbiochem®
同义词 [3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole, TβR-I Inhibitor, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor, ALK5 Inhibitor I, LY-364947, HTS-466284 参考 参考 Sawyer, J.S., et al. 2003. J. Med. Chem. 46, 3953.
Singh, J., et al. 2003. Bioorg. Med. Chem. Lett. 13, 4355.产品信息 CAS号 396129-53-6 具有ATP竞争性 Y 形式 Brown solid Hill配方 C₁₇H₁₂N₄ 化学配方 C₁₇H₁₂N₄ Molar Mass 272.3 可逆 Y 结构配方图像 生物信息 主靶 TGF-β receptor I kinase 主靶IC50 51 nM against TGF-β Receptor I kinase; 89 nM against TGF-β-dependent cellular growth in NIH 3T3 mouse fibroblasts; 47 nM against TGF-β-dependent transcription activation in mink lung cells 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Carcinogenic / Teratogenic
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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