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merck millipore,默克密理博,MAB3418A5,Anti-MAP2 Antibody, clone AP20, Alexa Fluor 555 Conjugate
产品名称：Anti-MAP2 Antibody, clone AP20, Alexa Fluor 555 Conjugate
产品型号：MAB3418A5
This Anti-MAP2 Antibody, clone AP20, Alexa Fluor 555 Conjugate is validated for use in ICC for the detection of MAP2.
merck millipore,默克密理博,MAB3418A5,Anti-MAP2 Antibody, clone AP20, Alexa Fluor 555 Conjugate
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, R, B, Ch, H ICC M AlexaFluor®555 Monoclonal Antibody 描述 产品目录编号 MAB3418A5 描述 Anti-MAP2 Antibody, clone AP20, Alexa Fluor® 555 Conjugate Alternate Names - MAP2
- Microtubule-associated protein 2
- MAP-2
背景信息 The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin, stabilizes microtubules (Herzog and Weber, 1978), and is an excellent marker for neurons. MAP-2 is essential for the development and maintenance of neuronal morphology (Matus, 1991). Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurons. (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules. 产品信息 格式 AlexaFluor®555 控制 - Rat E18 primary cortex cells
演示 Purified mouse monoclonal IgG conjugated to Alexa Fluor® 555 in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 This Anti-MAP2 Antibody, clone AP20, Alexa Fluor 555 Conjugate is validated for use in ICC for the detection of MAP2. 主要应用 - Immunocytochemistry
生物信息 免疫原品种 Bovine brain microtubule protein 克隆 AP20 宿主 Mouse 同种型 IgG 品种反应性 MouseRatBovineChickenHuman Species Reactivity Note Demonstrated to react with Rat. Predicted to react with Bovine, Chicken, Human, and Mouse based on 100% sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001039538.1
Entrez基因汇总 This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isforms have been described. 基因符号 - Mtap2
- Map2
纯化方法 Affinity purified UniProt编号 - P11137
UniProt汇总 Function The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Subcellular location Cytoplasm › cytoskeleton Probable.
Post-translational modification Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly By similarity. MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Isoform MAP2c is phosphorylated by FYN at Tyr-67. Ref.9 Ref.10 Ref.11 Ref.12 Ref.13
Sequence similarities Contains 3 Tau/MAP repeats.产品使用声明 质量保证 Evaluated by Immunocytochemistry in rat E18 primary cortex cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected MAP2 in rat E18 primary cortex cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 µL
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