merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5849-25UL,Anti-Glutamate Receptor 1 Antibody, phosphoSer 845

  • merck millipore,默克密理博,AB5849-25UL,Anti-Glutamate Receptor 1 Antibody, phosphoSer 845

    产品名称：Anti-Glutamate Receptor 1 Antibody, phosphoSer 845
    产品型号：AB5849-25UL
    This Anti-Glutamate Receptor 1 Antibody, phosphoSer 845 is validated for use in WB for the detection of Glutamate Receptor 1.

    merck millipore,默克密理博,AB5849-25UL,Anti-Glutamate Receptor 1 Antibody, phosphoSer 845

  • 产品介绍
  • merck millipore,默克密理博,AB5849-25UL,Anti-Glutamate Receptor 1 Antibody, phosphoSer 845

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5849-25UL
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Glutamate Receptor 1 Antibody, phosphoSer 845
    Alternate Names
    • GluR1
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
    应用
    应用 This Anti-Glutamate Receptor 1 Antibody, phosphoSer 845 is validated for use in WB for the detection of Glutamate Receptor 1.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:500-1:1,000

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to amino acids surrounding the phosphoSer845 of rat GluR1.
    表位 phosphoSer 845
    宿主 Rabbit
    特异性 Glutamate Receptor 1 [GluR1], phosphoSer845. The antibody recognizes a protein of 100 kDa corresponding to GluR1 phosphorylated at Ser845 in rat brain extracts. Immunolabeling is blocked by the phosphopeptide used as the immunogen but not non-phosphopeptide.
    品种反应性 Rat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000827.2
    Entrez基因汇总 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • MGC133252
    • GRIA1
    • GluR-K1
    • GLURA
    • HBGR1
    • GluR-A
    • GluR-1
    • GLUH1
    • GLUR1
    修改
    • Phosphorylation
    UniProt编号
    • P42261
    UniProt汇总 FUNCTION: SwissProt: P42261 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
    SIZE: 906 amino acids; 101506 Da
    SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with CACNG2 and RASGRF2 (By similarity).
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Interaction with CACNG2 promotes cell surface expression (By similarity).
    TISSUE SPECIFICITY: Widely expressed in brain.
    PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
    SIMILARITY: SwissProt: P42261 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
    MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.
    包装信息
    数量 25 µL

    merck millipore,默克密理博,AB5849-25UL,Anti-Glutamate Receptor 1 Antibody, phosphoSer 845

上一件merck millipore产品：merck millipore,默克密理博,217721,InSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,524753,TBS-TWEEN Tablets - Calbiochem


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