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merck millipore,默克密理博,MAB342A4,Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor488 Conjugate
产品名称：Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor488 Conjugate
产品型号：MAB342A4
Detect Galactocerebroside using this Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor488 Conjugate validated for use in ICC.
merck millipore,默克密理博,MAB342A4,Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor488 Conjugate
- 产品介绍
- merck millipore,默克密理博,MAB342A4,Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor488 Conjugate
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Ch, H, M, R, B ICC M AlexaFluor®488 Monoclonal Antibody 描述 产品目录编号 MAB342A4 描述 Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor®488 Conjugate Alternate Names - Galactosylceramide beta-galactosidase
- Galactocerebrosidase
- GALCERase
- Galactocerebroside beta-galactosidase
- Galactosylceramidase
背景信息 Galactocerebroside (GalC) is a major galactosphingolipid of myelin which plays a role in myelination. GalC is a very useful, specific marker for oligodendroglial lineage. 产品信息 格式 AlexaFluor®488 控制 - Rat oligodendrocyte cells
演示 Purified mouse monoclonal IgG3 conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 Detect Galactocerebroside using this Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor®488 Conjugate validated for use in ICC. 主要应用 - Immunocytochemistry
生物信息 免疫原品种 Synaptic plasma membranes from bovine hippocampus. 克隆 mGalC 宿主 Mouse 特异性 This antibody recognizes Galactocerebroside (GalC), sulfatide, psychosine and other galactolipids. Cross-reacts with the sulfatide ester of GalC, but to a 16-fold to a lesser extent. No cross-reactivity with sphingosine, ceramide, mixed ganglioside or glucocerebroside. Binds specifically with oligodendrocytes and Schwann cells. 同种型 IgG3 品种反应性 ChickenHumanMouseRatBovine Species Reactivity Note Demonstrated to react with Rat. Predicted to react with Mouse, Human, and Chicken. Predicted to react with Bovine based on immunogen design. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_000144
Entrez基因汇总 This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. 基因符号 - GALC
纯化方法 Protein A purified UniProt编号 - P54803
UniProt汇总 FUNCTION: Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
SIZE: 669 amino acids; 75147 Da
SUBCELLULAR LOCATION: Lysosome.
TISSUE SPECIFICITY: Highest level of activity in testes compared to brain, kidney, placenta and liver. Can also be found in urine.
DISEASE: Defects in GALC are the cause of globoid cell leukodystrophy (GLD) [MIM:245200]; also known as Krabbe disease. This autosomal recessive disorder results in the insufficient catabolism of several galactolipids that are important in the production of normal myelin. Clinically, the most frequent form is the infantile form. Most patients (90%) present before six months of age with irritability, spasticity, arrest of motor and mental development, and bouts of temperature elevation without infection. This is followed by myoclonic jerks of arms and legs, oposthotonus, hypertonic fits, and mental regression, which progresses to a severe decerebrate condition with no voluntary movements and death from respiratory infections or cerebral hyperpyrexia before 2 years of age. However, a significant number of cases with later onset, presenting with unexplained blindness, weakness and/or progressive motor, and sensory neuropathy that can progress to severe mental incapacity and death, have been identified.
SIMILARITY: Belongs to the glycosyl hydrolase 59 family.产品使用声明 质量保证 Evaluated by Immunocytochemistry in rat oligodendrocyte cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Galactocerebroside in rat oligodendrocyte cells. Performed without Triton.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 µL
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