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merck millipore,默克密理博,219465,Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem
产品名称：Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem
产品型号：219465
A cell-permeable dienone-phenolic triterpene compound that exhibits antioxidant and anti-inflammatory properties.
merck millipore,默克密理博,219465,Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem
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重要规格表
经验配方 CAS号 C₂₉H₃₈O₄ 34157-83-0 描述 概述 A cell-permeable dienone-phenolic triterpene compound that exhibits antioxidant and anti-inflammatory properties. It suppresses LPS-induced pro-inflammatory cytokines release in macrophages and monocytes (IC50 = 40 nM for IL-1β and IL-1α, 80 nM for IL-6, 110 nM for PGE2, and 210 nM for IL-8 and TNF-α), as well as LPS-induced NF-κB activation (IC50 = 270 nM) and NO production (IC50 = 230 nM) in RAW264.7 cells. Preferentially inhibits chymotrypsin-like activity of 20S proteasome with an IC50 of 2.5 µM. Has also been shown to inhibit lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50 = 7 µM). Significantly improves the performance in memory, learning, and psychomotor activity in rats. May be useful to minimize inflammation in Alzheimer′s disease (AD). 产品目录编号 219465 品牌系列 Calbiochem®
同义词 Tripterin, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid, Proteasome Inhibitor XIX 参考 参考 Yang, H., et al. 2006. Cancer Res. 66, 4758.
Westerheide, S.D., et al. 2004. J. Biol. Chem. 279, 56053.
Jin, H.Z., et al. 2002. J. Nat. Prod. 65, 89.
Allison, A.C., et al. 2001. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341.
He, W., et al. 1998. Bioorg. Med. Chem. Lett. 8, 3659.
Sassa, H., et al. 1990. Biochem. Biophys. Res. Commun. 172, 890.产品信息 CAS号 34157-83-0 具有ATP竞争性 N 形式 Red crystals Hill配方 C₂₉H₃₈O₄ 化学配方 C₂₉H₃₈O₄ Molar Mass 450.6 可逆 N 结构配方图像 生物信息 主靶 20S proteasome 主靶IC50 2.5 µM inhibiting chymotrypsin-like activity of 20S proteasome 纯度 ≥95% by TLC 理化信息 细胞可渗透 Y 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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