merck millipore,默克密理博,MABC758,Anti-KLKB1, clone EPR5707, Rabbit Monoclonal Antibody

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merck millipore,默克密理博,MABC758,Anti-KLKB1, clone EPR5707, Rabbit Monoclonal Antibody
产品名称：Anti-KLKB1, clone EPR5707, Rabbit Monoclonal Antibody
产品型号：MABC758
This Anti-KLKB1, clone EPR5707, Rabbit Monoclonal Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of KLKB1.

merck millipore,默克密理博,MABC758,Anti-KLKB1, clone EPR5707, Rabbit Monoclonal Antibody

产品介绍

merck millipore,默克密理博,MABC758,Anti-KLKB1, clone EPR5707, Rabbit Monoclonal Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABC758
描述	Anti-KLKB1, clone EPR5707, Rabbit Monoclonal Antibody
Alternate Names	Plasma prekallikrein Plasma kallikrein Fletcher factor Kininogenin
背景信息	Plasma kallikrein, also known as Fletcher factor or Kininogenin or Plasma prekallikrein, and encoded by the gene name KLKB1 or KLK3, is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. KLKB1 is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. This protein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of KLKB1. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Mutations in KLKB1 have been associated with Prekallikrein deficiency.

产品信息
格式	Unpurified
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	This Anti-KLKB1, clone EPR5707, Rabbit Monoclonal Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of KLKB1.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:50-100 dilution from a representative lot detected KLKB1 in human kidney tissue. Produced in collaboration with Epitomics™

生物信息
免疫原品种	Synthetic peptide corresponding to the C-terminus of human KLKB1.
表位	C-terminus
克隆	EPR5707
浓缩	Please refer to lot specific datasheet.
宿主	Rabbit
同种型	IgG
品种反应性	Human
Species Reactivity Note	Human
抗体类型	Monoclonal Antibody
基因符号	KLK3 KLKB1
纯化方法	Unpurified
UniProt编号	P03952

产品使用声明
质量保证	Evaluated by Western Blotting in human breast cancer, human plasma, human ovary, and human fetal liver lysates. Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected KLKB1 in human breast cancer, human plasma, human ovary, and human fetal liver lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.