merck millipore,默克密理博,172050,Anacardic Acid - CAS 16611-84-0

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Merck Millipore 默克密理愽

merck millipore,默克密理博,172050,Anacardic Acid - CAS 16611-84-0 - Calbiochem

经验配方	CAS号
C₂₂H₃₆O₃	16611-84-0

描述
概述	A cell-permeable ginkgolic acid (Cat. No. 345887) analog that inhibits protein SUMO (Cat. Nos. 662037, 662039, and 662042) modification (IC₅₀ = 2.2 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. Nos. 662073 and 662074) and interfering with E1-SUMO intermediate formation. Both anacardic acid and ginkgolic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although anacardic acid is shown to inhibit p300 (Cat. No. 506200) and PCAF (Cat. No. 124026) histone acetyltransferase activities in cell-free acetylase assays (by 82% and 86%, respectively, at 10 µM). Also reported to inhibit the activity of prostaglandin synthase, tyrosinase, and lipoxygenase, as well as to enhance Aurora kinase A (Cat. No. 481413), but not Aurora kinase B, autophosphorylation and kinase activity by inducing conformation change and enhancing ATP binding.
产品目录编号	172050
品牌系列	Calbiochem®
同义词	AA, 2-Hydroxy-6-pentadecylbenzoic Acid, 6-Pentadecylsalicylic Acid, Aurora Kinase A Activator, Histone Acetyltransferase Inhibitor III, SUMOylation Inhibitor II, HAT Inhibitor III, p300/CBP Inhibitor III, PCAF Inhibitor I

参考
参考	Fukuda, I., et al. 2009. Chem. Biol. 16, 133. Kishore, A.H. 2008. J. Med. Chem. 51, 792. Balasubramanyam, K., et al. 2003. J. Biol. Chem. 278, 19134. Paramashivappa, R., et al. 2002. J. Agric. Food Chem. 50, 7709.

产品信息
CAS号	16611-84-0
具有ATP竞争性	Y
声明	Sold under license of U.S. Patent 7,332,629 and related patents.
形式	White solid
Hill配方	C₂₂H₃₆O₃
化学配方	C₂₂H₃₆O₃
Molar Mass	348.5
可逆	N
结构配方图像

生物信息
主靶	HAT
主靶IC₅₀	5 µM against HAT; 8.5 µM against PCAF; 2.2 µM inhibiting protein SUMO modification using RanGAP1-C2 as substrate
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO, MeOH, or EtOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,172050,Anacardic Acid - CAS 16611-84-0 - Calbiochem

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