merck millipore,默克密理博,MABS455,Anti-GLEPP1 Antibody, extracellular domain, clone 1B4

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R	WB, IHC	M	Purified	Monoclonal Antibody

描述
产品目录编号	MABS455
描述	Anti-GLEPP1 Antibody, extracellular domain, clone 1B4
Alternate Names	Protein tyrosine phosphatase, receptor type, O, isoform Protein Ptpro Protein tyrosine phosphatase D30
背景信息	YGlomerular epithelial protein 1 (GLEPP1) is a membrane bound tyrosine phosphatase present on the apical cell surface that plays a role in regulating the glomerular pressure filtration rate by regulating podocyte structure and function. GLEPP1 is expressed in the kidney but also in brain, lung and placenta. In the brain, GLEPP1 plays an important role in axon guidance, and in other cells GLEPP1 assists in lamellipodium assembly. Because of its action on lamellipodia, GLEPP1 is important in cellular chemotaxis, thus inhibitors to GLEPP1 function aid in treatments where the migration of inflammatory cells are affected such as in ulcerative colitis. Finally, because phosphorylation and its reversal via phosphatases are key signaling and regulatory events, a variety of syndromes are associated with genetic variations associated with phosphatase mutations. For GLEPP1, various nephrotic syndromes such as NPHS6 and hyper-proteinuria disease are associated with mutations in the GLEPP1 coding region.

产品信息
格式	Purified
演示	Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	This Anti-GLEPP1 Antibody, extracellular domain, clone 1B4 is validated for use in Immunohistochemistry and Western Blotting for the detection of GLEPP1, extracellular domain.
主要应用	Western Blotting Immunohistochemistry
应用说明	Immunohistochemistry Analysis: A representative lot detected GLEPP1, extracellular domain in isolated rat glomeruli tissue (Wharram, B.L., et al. (2005) J Am Soc Nephrol. 16:2941–2952; Fukuda, A., et al. (2012). Kidney International. 81:40-55; Kim, Y.H., (2001). Kidney International. 60:957-968). Western Blotting Analysis: A representative lot detected GLEPP1, extracellular domain in rat isolated glomeruli tissue lysate (Fukuda, A., et al. (2012). J Am Soc Nephrol. 23:1351–1363).

生物信息
免疫原品种	Recombinant protein corresponding to rat GLEPP1, extracellular domain.
克隆	1B4
浓缩	1 mg/mL
宿主	Mouse
同种型	IgG2aκ
品种反应性	Rat
Species Reactivity Note	Rat.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_059032
基因符号	Ptpro
纯化方法	Protein G purified
UniProt编号	Q62797

产品使用声明
质量保证	Evaluated by Immunohistochemistry in glomeruli of rat kidney tissue. Immunohistochemistry Analysis: A 1:50-250 dilution of this antibody detected GLEPP1, extracellular domain in glomeruli of rat kidney tissue.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µL

merck millipore,默克密理博,MABS455,Anti-GLEPP1 Antibody, extracellular domain, clone 1B4

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