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merck millipore,默克密理博,MAB1904,Anti-Laminin-1 A&B chains Antibody, cross region, clone AL-2
产品名称：Anti-Laminin-1 A&B chains Antibody, cross region, clone AL-2
产品型号：MAB1904
Detect Laminin-1 A&B chains using this Anti-Laminin-1 A&B chains Antibody, cross region, clone AL-2 validated for use in ELISA, IF, IH(P), IP & WB.
merck millipore,默克密理博,MAB1904,Anti-Laminin-1 A&B chains Antibody, cross region, clone AL-2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M WB, ELISA R Purified Monoclonal Antibody 描述 产品目录编号 MAB1904 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Laminin-1 A&B chains Antibody, cross region, clone AL-2 Alternate Names - laminin beta1
- laminin alpha1
背景信息 Laminins are secreted glycoproteins incorporated into cell-associated extracellular matrices and an integral part of the structural scaffolding in most animal tissues. The laminin protein is made up of three polypeptide chains; α, β and γ, accounting for its flexibility in connecting various molecules. When originally characterized, laminin-1 clone AL-2 reacted with Engelbreth-Holm-Swarm (EHS) mouse laminin A & B chains on the long arm near the cross region, (Skubitz, 1987). More recently, investigations, (Schèele, 2006) have shown that the clone binds laminin β1 under reducing conditions as well as native ELISAs and that the affinity is increased by the presence of the laminin α1 chain. Thus there is significant laminin β1 reactivity with clone AL-2. 产品信息 格式 Purified 演示 Purified in 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% NaN3. 应用 应用 Detect Laminin-1 A&B chains using this Anti-Laminin-1 A&B chains Antibody, cross region, clone AL-2 validated for use in ELISA, IF, IH(P), IP & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Immunofluorescence:
An independent laboratory (Schèele, S., 2006) has verified anti-laminin clone AL-2 to work using immunofluorescence techniques on mouse muscle tissue, including both transgenic and wild-type tissues.生物信息 免疫原品种 Laminin isolated from EHS mouse sarcoma. 表位 Near cross region 克隆 AL-2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 特异性 Reacts with EHS mouse laminin A & B chains on the long arm near the cross region. 同种型 IgG1κ 品种反应性 Mouse Species Reactivity Note Reacts with mouse. Other species have not been tested. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005559.2
基因符号 - LAMA
- LAMA1
纯化方法 Protein G purfied UniProt编号 - P55268
- P25391
UniProt汇总 FUNCTION: SwissProt: P55268 # Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
SIZE: 1798 amino acids; 195981 Da
SUBUNIT: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (S-laminin), laminin-4 (S- merosin), and laminin-7 (KS-laminin).
SUBCELLULAR LOCATION: Secreted, extracellular space. Note=S- laminin is concentrated in the synaptic cleft of the neuromuscular junction.
DOMAIN: SwissProt: P55268 The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. & Domains VI and IV are globular.
DISEASE: SwissProt: P55268 # Defects in LAMB2 are the cause of Pierson syndrome [MIM:609049]; also known as microcoria-congenital nephrotic syndrome. Pierson syndrome is characterized by nephrotic syndrome with neonatal onset, diffuse mesangial sclerosis and eye abnormalities with microcoria as the leading clinical feature. Death usually occurs within the first weeks of life. Disease severity depends on the mutation type: nontruncating LAMB2 mutations may display variable phenotypes ranging from a milder variant of Pierson syndrome to isolated congenital nephrotic syndrome. & Defects in LAMB2 are a cause of congenital nephrotic syndrome [MIM:609049]. Congenital nephrotic syndrome constitutes a heterogeneous group of conditions having in common the disruption of normal glomerular permselectivity. Congenital nephrotic syndrome due to LAMB2 mutations may be associated with ocular abnormalities.
SIMILARITY: Contains 13 laminin EGF-like domains. & Contains 1 laminin IV type B domain. & Contains 1 laminin N-terminal domain.产品使用声明 质量保证 Evaluated on a representative lot by Western blot on purified mouse laminin-1. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. 包装信息 数量 100 µg
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