merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB19310,Anti-Aggrecan Antibody, MMP Cleaved, NT FFGVG neoepitopes, clone AF-28

  • merck millipore,默克密理博,MAB19310,Anti-Aggrecan Antibody, MMP Cleaved, NT FFGVG neoepitopes, clone AF-28

    产品名称：Anti-Aggrecan Antibody, MMP Cleaved, NT FFGVG neoepitopes, clone AF-28
    产品型号：MAB19310
    Detect Aggrecan using this Anti-Aggrecan Antibody, MMP Cleaved, N-terminus FFGVG neoepitopes, clone AF-28 validated for use in ELISA & WB.

    merck millipore,默克密理博,MAB19310,Anti-Aggrecan Antibody, MMP Cleaved, NT FFGVG neoepitopes, clone AF-28

  • 产品介绍
  • merck millipore,默克密理博,MAB19310,Anti-Aggrecan Antibody, MMP Cleaved, NT FFGVG neoepitopes, clone AF-28

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, B, H, M, PoWB, ELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB19310
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Aggrecan Antibody, MMP Cleaved, NT FFGVG neoepitopes, clone AF-28
    背景信息 Aggrecan is also known as aggregating chondroitin sulphate proteoglycan. Aggrecan is the major proteoglycan present in articular cartilage, composing up to 10% of its dry weight. It is responsible for endowing articular with its intrinsic properties of load bearing and compressive forces.
    产品信息
    格式 Purified
    控制
    • Cartilage, neural tube, and brain tissue
    演示 Liquid in PBS pH 7.4 containing 0.09% sodium azide as a preservative.
    应用
    应用 Detect Aggrecan using this Anti-Aggrecan Antibody, MMP Cleaved, N-terminus FFGVG neoepitopes, clone AF-28 validated for use in ELISA & WB.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Western blot

    ELISA

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 FFGVGGEEDC-KLH peptide
    表位 N-terminus FFGVG neoepitopes
    克隆 AF-28
    宿主 Mouse
    特异性 Mouse anti-aggrecan is a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments. The antibody recognizes neo-epitopes on polypeptides with N-terminal FFGVG sequences. This sequence is found at the N-terminus of aggrecan fragments that have been digested with MMPs. By immunoblotting, AF-28 specifically detected G2 fragments derived from an aggrecan G1-G2 substrate digested with stromelysin, collagenase, gelatinase, and matrilysin, but failed to detect G2 fragments obtained from elastase, trypsin, or cathepsin B digests. Undigested G1-G2 was not detected. Competition experiments confirmed that peptides containing internal FFGVG sequences were not detected by the antibody. Clone AF-28 specifically recognizes a neo-epitope on polypeptides with N-terminal FFGVG Sequences. This sequence is found at the N-terminus of aggrecan fragments that have been digested with matrix metalloproteinases.
    同种型 IgG1
    品种反应性 RatBovineHumanMousePig
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_013227.2
    • NM_001135.2
    Entrez基因汇总 This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.
    基因符号
    • CSPGCP
    • ACAN
    • MSK16
    • SEDK
    • CSPCP
    • AGCAN
    • AGC1
    • CSPG1
    非反应性品种
    • Guinea Pig
    • Horse
    纯化方法 Protein A purfied
    UniProt编号
    • P16112
    UniProt汇总 FUNCTION: SwissProt: P16112 # This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
    SIZE: 2415 amino acids; 250193 Da
    SUBUNIT: Interacts with FBLN1 (By similarity).
    SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
    TISSUE SPECIFICITY: Restricted to cartilages.
    DEVELOPMENTAL STAGE: Expression was detected in chondrocytes throughout the developing skeleton.
    DOMAIN: SwissProt: P16112 Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.
    PTM: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.
    DISEASE: SwissProt: P16112 # Defects in AGC1 are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.
    SIMILARITY: Belongs to the aggrecan/versican proteoglycan family. & Contains 1 C-type lectin domain. & Contains 1 EGF-like domain. & Contains 1 Ig-like V-type (immunoglobulin-like) domain. & Contains 4 Link domains. & Contains 1 Sushi (CCP/SCR) domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB19310,Anti-Aggrecan Antibody, MMP Cleaved, NT FFGVG neoepitopes, clone AF-28

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