merck millipore,默克密理愽
  • merck millipore,默克密理博,14-453M,Akt1/PKBα (δPH, S473D) Protein, active, 250 µg

  • merck millipore,默克密理博,14-453M,Akt1/PKBα (δPH, S473D) Protein, active, 250 µg

    产品名称：Akt1/PKBα (δPH, S473D) Protein, active, 250 µg
    产品型号：14-453M
    Active, N-terminal His6-tagged, recombinant human Akt1, residues 118-end containing the mutation S473D, for use in Kinase Assays.

    merck millipore,默克密理博,14-453M,Akt1/PKBα (δPH, S473D) Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-453M,Akt1/PKBα (δPH, S473D) Protein, active, 250 µg

    描述
    产品目录编号 14-453M
    品牌系列 Upstate
    商名
    • Upstate
    描述 Akt1/PKBα (δPH, S473D) Protein, active, 250 µg
    概述 N-terminal His6-tagged, recombinant human Akt1, residues 118-end containing the mutation S473D
    应用
    应用 Active, N-terminal His6-tagged, recombinant human Akt1, residues 118-end containing the mutation S473D, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Human Akt1 expressed by baculovirus in Sf21 insect cells.
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_001014431.1
    • NM_001014432.1
    • NM_005163.2
    Entrez基因汇总 The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene.
    基因符号
    • AKT
    • AKT1
    • RAC
    • PRKBA
    • MGC99656
    • RAC-ALPHA
    • RAC-PK-alpha
    • C-AKT
    • PKB
    蛋白靶 Akt1/PKBα
    纯化方法 Ni2+/NTA-agarose
    靶子系列 AGC
    UniProt编号
    • P31749
    UniProt汇总 FUNCTION: SwissProt: P31749 # General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4E-BP1 and in insulin-induced activation of p70 S6 kinase. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.
    SIZE: 480 amino acids; 55686 Da
    SUBUNIT: Interacts with CENTG1 isoform 2 (PIKE-A) in the presence of guanine nucleotides. The C-terminus interacts with CCDC88A/GRDN. Interacts with AKTIP.
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1).
    TISSUE SPECIFICITY: In all human cell types so far analyzed.
    DOMAIN: SwissProt: P31749 Binding of the PH domain to the phosphatidylinositol 3- kinase alpha (PI(3)K) results in its targeting to the plasma membrane.
    PTM: Phosphorylation on Thr-308, Ser-473 and Tyr-474 is required for full activity. Ser-473 phosphorylation by the Rictor-mTor complex favors Thr-308 phosphorylation by PDPK1. Ser-473 phosphorylation is enhanced by interaction with CENTG1 isoform 2 (PIKE-A).
    SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 PH domain. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of Crosstide substrate peptide
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-453) and in bulk (cat# 14-453-K).

    merck millipore,默克密理博,14-453M,Akt1/PKBα (δPH, S473D) Protein, active, 250 µg

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