merck millipore,默克密理愽
  • merck millipore,默克密理博,482740,nNOS - PSD-95 Interaction Inhibitor, ZL006 - Calbiochem

  • merck millipore,默克密理博,482740,nNOS - PSD-95 Interaction Inhibitor, ZL006 - Calbiochem

    产品名称：nNOS - PSD-95 Interaction Inhibitor, ZL006 - Calbiochem
    产品型号：482740
    The nNOS - PSD-95 Interaction Inhibitor, ZL006 controls the biological activity of nNOS. This small molecule/inhibitor is primarily used for Cancer applications.

    merck millipore,默克密理博,482740,nNOS - PSD-95 Interaction Inhibitor, ZL006 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,482740,nNOS - PSD-95 Interaction Inhibitor, ZL006 - Calbiochem

    重要规格表

    经验配方
    C₁₄H₁₁Cl₂NO₄
    描述
    概述 A cell-permeable and blood-brain barrier-permeant aminosalicylic acid compound that selectively disrupts nNOS and PSD-95 interaction upon NMDAR activation both in primary murine cortical neurons (0.8- and 2.8-fold increase from basal level with or without 30 min 10 uM ZL006 pretreatment) in vitro and in mice (0.4- and 1.9-fold increase from basal level with or without inhibitor pretreatment 15 min before ischemia; 1.5 mg/kg i.v.) in vivo without affecting nNOS activity or non-nNOS-mediated NMDAR EPSCs (excitatory postsynaptic currents). Effectively reduce ischemia-caused brain tissue damage in both mice and rats when applied 1 h after blood reperfusion following ishemia (60% and 50% reduction of infarction, respectively; 1.5 mg/kg i.v.).
    产品目录编号 482740
    品牌系列 Calbiochem®
    同义词 5-(3,5-dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic acid
    参考
    参考 Zhou, L., et al. 2010. Nature Med. 16, 1439.
    产品信息
    形式 Off-white solid
    Hill配方 C₁₄H₁₁Cl₂NO₄
    化学配方 C₁₄H₁₁Cl₂NO₄
    Molar Mass 328.2
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Regulatory Review
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,482740,nNOS - PSD-95 Interaction Inhibitor, ZL006 - Calbiochem

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