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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-864 品牌系列 Upstate
商名 - Upstate
描述 Anti-FLIP Antibody, CT 产品信息 格式 Purified 演示 PBS, pH 7.4, 0.02% sodium azide before the addition of glycerol to 30% 应用 应用 Detect FLIP using this Anti-FLIP Antibody, CT validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide corresponding to amino acids 447-464 [NGYMYDWNSRVSAKEKYY] of human FLIP 宿主 Rabbit 特异性 long form of FLIP 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003879
基因符号 - FLAME-1
- CFLAR
- I-FLICE
- CASP8AP1
- Casper
- Usurpin
- FLIP
- c-FLIPS
- FLAME
- CASH
- c-FLIPL
- CLARP
- USURPIN
- c-FLIPR
- c-FLIP
- MRIT
纯化方法 Protein A chromatography UniProt编号 - O15519
UniProt汇总 FUNCTION: SwissProt: O15519 # Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
SIZE: 480 amino acids; 55344 Da
SUBUNIT: TNFRSF6 stimulation triggers recruitment to the death- inducing signaling complex (DISC) formed by TNFRSF6, FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with caspase-10, caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X.
TISSUE SPECIFICITY: Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
DOMAIN: SwissProt: O15519 The caspase domain lacks the active sites residues involved in catalysis.
PTM: Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.
SIMILARITY: Belongs to the peptidase C14 family. & Contains 2 DED (death effector) domains.产品使用声明 质量保证 routinely evaluated by immunoblot on Jurkat, A431, Raji, 3T3, CTLL, PC12 or L6 RIPA cell lysates 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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