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merck millipore,默克密理博,229103,Choline Kinase-a Inhibitor, CK37 - CAS 1001478-90-5 - Calbiochem
产品名称：Choline Kinase-a Inhibitor, CK37 - CAS 1001478-90-5 - Calbiochem
产品型号：229103
The Choline Kinase-α Inhibitor, CK37, also referenced under CAS 1001478-90-5, controls the biological activity of Choline Kinase-α. This small molecule/inhibitor is primarily used for Phosphorylation More>>
merck millipore,默克密理博,229103,Choline Kinase-a Inhibitor, CK37 - CAS 1001478-90-5 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₀H₂₂N₄OS 1001478-90-5 描述 概述 A cell-permeable, non-Hemicholinium-3 derivative and choline-competitive choline kinase-α inhibitor. It is demonstrated to inhibit endogenous choline kinase activity, dose-dependently, between 1-10 µM, and dose-dependently decrease phosphocholine concentrations, as well as levels of downstream choline metabolites, including phosphatidylcholine and phosphatidic acid in HeLa cells. At 10 µM, it is also shown to attenuate MAPK and PI3K/AKT signaling, and disrupt the actin cytoskeleton and membrane ruffling, consistent with siRNA choline kinase-&alpha transfection. This compound exhibits dose-dependent suppression of cell growth in six tumor cell lines (IC50 = 5-10 µM), in vitro. Furthermore, it is shown to suppress tumor growth in a mouse model by 48% at 0.08 mg/g daily dose for 8 days without obvious toxicity, in vivo. 产品目录编号 229103 品牌系列 Calbiochem®
同义词 CK37, N-(3,5-dimethyl-dimethylphenyl)-2-[[5-(4-ethylphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide 参考 参考 Clem, B., et al. 2011. Oncogene 30, 3370. 产品信息 CAS号 1001478-90-5 形式 Tan powder Hill配方 C₂₀H₂₂N₄OS 化学配方 C₂₀H₂₂N₄OS Molar Mass 366.48 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°c. 包装信息 惰性气体下包装 Packaged under inert gas
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