- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,MAB1334,Anti-Collagen Types I, II & III Antibody, clone MMCHABC
产品名称：Anti-Collagen Types I, II & III Antibody, clone MMCHABC
产品型号：MAB1334
Anti-Collagen Types I, II & III Antibody, clone MMCHABC detects level of Collagen Types I & has been published & validated for use in ELISA, RIA, IH.
merck millipore,默克密理博,MAB1334,Anti-Collagen Types I, II & III Antibody, clone MMCHABC
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, ELISA M Purified Monoclonal Antibody 描述 产品目录编号 MAB1334 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Collagen Types I, II & III Antibody, clone MMCHABC Alternate Names - Interstitial Collagens
产品信息 格式 Purified 演示 Purified from murine ascites by PEG precipitation and Sepharose™ CL-4B chromatography. Lyophilized Powder. 应用 应用 Anti-Collagen Types I, II & III Antibody, clone MMCHABC detects level of Collagen Types I & has been published & validated for use in ELISA, RIA, IH. 主要应用 - Immunohistochemistry
- ELISA
不建议的应用 - Western Blotting
应用说明 ELISA: Apparent binding constant from titration curves is 0.1 nM. Can be used as capture or reporter antibody for determination of collagen I or III in sandwich ELISA, but requires combination with collagen type-specific antibody for other function.
Immunohistochemistry: cryostat sections fixed with acetone or ethanol. Staining pattern similar to polyclonal antibody to interstitial collagens. Formaldehyde fixation is not recommended.
Not suitable for use on paraffin embedded sections or immunoblots.
Optimal working dilution must be determined by the end user.生物信息 免疫原品种 Human collagen type I 克隆 MMCHABC 宿主 Mouse 特异性 Human collagen types I, II and III (both native and denatured). No cross reactivity with human plasma proteins, other collagen types or non-collagenous proteins in ELISA, RIA or immunoblot. 同种型 IgM 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000088.3
Entrez基因汇总 This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish] 基因符号 - OI4
- COL1A1
UniProt编号 - P02461
- P02452
- P02458
UniProt汇总 FUNCTION: SwissProt: P02461 # Collagen type III occurs in most soft connective tissues along with type I collagen.
SIZE: 1466 amino acids; 138564 Da
SUBUNIT: Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
PTM: Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
DISEASE: SwissProt: P02461 # Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type III (EDS-III) [MIM:130020]; also known as benign hypermobility syndrome. Inheritance is autosomal dominant. EDS is characterized by joint laxity and hyperextensible skin. It is divided into nine different subtypes based on biochemical and clinical variations. & Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type IV (EDS-IV) [MIM:130050]. EDS-IV is the most severe form of the disease, in that it often produces life-threatening consequences, such as rupture of the arteries, bowel, or uterus. A variant form of EDS-IV is Gottron type acrogeria [MIM:201200]. The main characteristics are atrophy and mottled-type hyperpigmentation of the acral skin, resulting in an aged appearance. & Defects in COL3A1 may be a cause of aortic aneurysm [MIM:100070]. Aortic aneurysm consists of a dangerous ballooning of the aorta which is caused by a defect in the artery's wall.
SIMILARITY: SwissProt: P02461 ## Belongs to the fibrillar collagen family. & Contains 1 VWFC domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,UFC500324,Amicon Ultra-0.5 Centrifugal Filter Unit with Ultracel-3 membrane
下一件merck millipore产品：merck millipore,默克密理博,ABE70,Anti-BAF180 Antibody
相关产品
merck millipore,默克密理博,06-1091,Anti-IL-13 receptor Antibody, alpha-2 (IL-13RA2)
merck millipore,默克密理博,ABE285,Anti-Tristetraprolin Antibody
merck millipore,默克密理博,538903,Prostaglandin E₁ - CAS 745-65-3 - Calbiochem
merck millipore,默克密理博,260684,1-Deoxynojirimycin, Hydrochloride - CAS 73285-50-4 - Calbiochem
merck millipore,默克密理博,UFC500324,Amicon Ultra-0.5 Centrifugal Filter Unit with Ultracel-3 membrane
merck millipore,默克密理博,ABE70,Anti-BAF180 Antibody
merck millipore,默克密理博,05-495,Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone 8-5-2
merck millipore,默克密理博,14-545M,NEK2 Protein, active, 250 µg
merck millipore,默克密理博,324673,EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem
merck millipore,默克密理博,420142,JNK Inhibitor XI, BI-87G3 - CAS 2207-44-5 - Calbiochem