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merck millipore,默克密理博,ABE70,Anti-BAF180 Antibody
产品名称：Anti-BAF180 Antibody
产品型号：ABE70
Anti-BAF180 Antibody is a Rabbit Polyclonal Antibody for detection of BAF180 also known as protein polybromo-1, BRG1-associated factor 180 & has been validated in WB.
merck millipore,默克密理博,ABE70,Anti-BAF180 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H, R ChIP, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 ABE70 描述 Anti-BAF180 Antibody Alternate Names - Polybromo-1D
- polybromo 1
- protein polybromo-1
- BRG1-associated factor 180
- polybromo-1D
背景信息 BRG1-associated factor 180 (BAF180) is a subunit of the SWI/SNF-B (PBAF) chromatin remodeling complex, and is known to contain 6 bromo domains, 2 BAH domains, and a single HMG box DNA-binding domain. BAF180 has a critical and active role in the transcriptional activation and repression of specific genes via chromatin remodeling, including genes involved in the development of the heart, thus suggesting a role in mammalian development. Recent studies demonstrate BAF180 to suppress tumorigenesis through its ability to regulate both baseline and signal-dependent p21 transcription by its binding of the p21 promoter. Expression of BAF180 is reported in a wide range of tissues. 产品信息 格式 Purified 控制 - HEK293 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-BAF180 Antibody is a Rabbit Polyclonal Antibody for detection of BAF180 also known as protein polybromo-1, BRG1-associated factor 180 & has been validated in WB. 主要应用 - Chromatin Immunoprecipitation (ChIP)
- Western Blotting
应用说明 Chromatin Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in ChIP (Xia, W., et al. (2008). 生物信息 免疫原品种 GST-tagged recombinant protein corresponding to human BAF180. 宿主 Rabbit 品种反应性 MouseHumanRat 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_060635
基因符号 - hPB1
- PB1
- BAF180
- PBRM1
纯化方法 Protein G Purified UniProt编号 - Q86U86
UniProt汇总 FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).
SUBUNIT STRUCTURE: Component of the SWI/SNF-B (PBAF) chromatin-remodeling complex, which contains at least SMARCA4/BRG1, SMARCB1/SNF5/INI1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin. Interacts with PHF10/BAF45A (By similarity).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICTY: Widely expressed.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SEQUENCE SIMILARITIES: Contains 2 BAH domains.
Contains 6 bromo domains.
Contains 1 HMG box DNA-binding domain.
SEQUENCE CAUTION: The sequence AAI15010.1 differs from that shown. Reason: Contaminating sequence.
The sequence AAI15011.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAI15012.1 differs from that shown. Reason: Erroneous termination at position 78. Translated as Arg.
The sequence BAB71210.1 differs from that shown. Reason: Erroneous initiation.产品使用声明 质量保证 Evaluated by Western Blot in HEK293 cell lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected BAF180 in 10 µg of HEK293 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,05-495,Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone 8-5-2
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