merck millipore,默克密理愽
  • merck millipore,默克密理博,14-545M,NEK2 Protein, active, 250 µg

  • merck millipore,默克密理博,14-545M,NEK2 Protein, active, 250 µg

    产品名称：NEK2 Protein, active, 250 µg
    产品型号：14-545M
    Active, N-terminal His6-tagged, recombinant, full-length, human NEK2, for use in Kinase Assays.

    merck millipore,默克密理博,14-545M,NEK2 Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-545M,NEK2 Protein, active, 250 µg

    描述
    产品目录编号 14-545M
    品牌系列 Upstate
    商名
    • Upstate
    描述 NEK2 Protein, active, 250 µg
    概述 N-terminal His6-tagged, recombinant, full-length, human NEK2
    应用
    应用 Active, N-terminal His6-tagged, recombinant, full-length, human NEK2, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed by baculovirus in Sf21 cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002497.2
    基因符号
    • HsPK21
    • NEK2
    • NLK1
    • NLK
    • NEK2A
    蛋白靶 NEK2
    纯化方法 Ni2+/NTA-agarose
    靶子系列 Misc
    UniProt编号
    • P51955
    UniProt汇总 FUNCTION: SwissProt: P51955 # Protein kinase that is involved in mitotic regulation. May have a role at the G2-M transition. May also play a role in meiosis. Isoform 1 but not isoform 2 appears to play a role in centrosome splitting. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.
    COFACTOR: Magnesium.
    SIZE: 445 amino acids; 51763 Da
    SUBUNIT: Interacts with TERF1. Isoform 1 and isoform 2 form homo- and heterodimers.
    SUBCELLULAR LOCATION: Nucleus. & Isoform 1: Nucleus, nucleolus. Note=Has a nucleolar targeting/ retention activity via a coiled-coil domain at the C-terminal end. & Isoform 2: Cytoplasm. Note=Predominantly cytoplasmic.
    TISSUE SPECIFICITY: Isoform 1 and isoform 2 are expressed in peripheral blood T-cells and a wide variety of transformed cell types.
    DEVELOPMENTAL STAGE: Accumulates throughout S phase and shows maximal levels in late G2. This expression pattern is highly reminiscent of that of A and B cyclins. Expression of both isoform 1 and isoform 2 is low in the G1 phase and increases in the S/G2 phases. Isoform 1 is absent from cells arrested in the G2/M prometaphase, whereas isoform 2 remains present.
    SIMILARITY: SwissProt: P51955 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. NIMA subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of MBP
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-545) and in bulk (cat# 14-545-K).

    merck millipore,默克密理博,14-545M,NEK2 Protein, active, 250 µg

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