merck millipore,默克密理愽
  • merck millipore,默克密理博,05-495,Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone 8-5-2

  • merck millipore,默克密理博,05-495,Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone 8-5-2

    产品名称：Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone 8-5-2
    产品型号：05-495
    Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone 8-5-2 is a mouse monoclonal antibody for detection of phospho-STAT5A/B (Tyr694/699) also known as signal transducer & activator of transcription 5A/B More>>

    merck millipore,默克密理博,05-495,Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone 8-5-2

  • 产品介绍
  • merck millipore,默克密理博,05-495,Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone 8-5-2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Sh, H, M, R, BWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-495
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone 8-5-2
    Alternate Names
    • signal transducer and activator of transcription 5A
    背景信息 STAT (Signal Transducers and Activators of Transcription) are a family of conserved transcription factors that transduce high-fidelity signals for the cytokine family of ligands and receptors as the principle substrates of JAK kinases (1,2). In resting cells, the STATs exist in an inactive state in the cytoplasm until activated. Activators include cytokines, growth factors, and some peptides. These activate JAK kinases, which when activated, bind to the STAT SH2 (Src homology domain-2) domain resulting in phosphorylation of STAT (1). Upon activation, STAT1, -3, -4, -5A, and -5B all form homodimers. STAT1 and STAT2, as well as STAT1 and STAT3 form heterodimers, and several STATs form tetramers, depending on the variables of the activating ligand (1). After dimerization, the STATs accumulate in the nucleus by way of nuclear transport (1). STAT5A and STAT5B appear to be most important to the function of growth hormone and prolactin and play critical roles in milk production (1,2,3). The phosphorylation of Tyrosine 694/699 is a hallmark of activated STAT5.
    产品信息
    格式 Purified
    控制
    • IFN-α induced HeLa cells or GM-CSF treated TF-1 cells
    演示 Purified mouse monoclonal IgG in buffer containing PBS. Frozen solution at -20°C.
    应用
    应用 Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone 8-5-2 is a mouse monoclonal antibody for detection of phospho-STAT5A/B (Tyr694/699) also known as signal transducer & activator of transcription 5A/B & has been validated in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated, synthetic phosphopeptide (KAVDG[pY]VKPQIK) corresponding to amino acids 689-700 of STAT5A and 694-705 of STAT5B. Clone 8-5-2.
    表位 Tyr694/699
    克隆 clone 8-5-2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Specific for the phosphorylated tyrosine residue 694 of STAT5A (94kDa) and 699 of STAT5B (92kDa). Unidentified proteins may be detected in some lysates.
    同种型 IgG
    品种反应性 SheepHumanMouseRatBovine
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_003152.2
    Entrez基因汇总 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
    基因符号
    • STAT5
    • STAT5A
    • MGF
    修改
    • Phosphorylation
    纯化方法 Protein G purfied
    UniProt编号
    • P51692
    UniProt汇总 FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
    SUBUNIT STURCTURE: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 By similarity. Interacts with NCOA1, NMI and SOCS7.
    SUBCELLULAR LOCATION: CytoplasmBy similarity. NucleusBy similarity. Note= Translocated into the nucleus in response to phosphorylation By similarity.
    PTM: Tyrosine phosphorylated By similarity.
    INVOLVEMENT IN DISEASE: Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.
    SEQUENCE SIMILARITIES: Belongs to the transcription factor STAT family.
    Contains 1 SH2 domain.
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on 3T3/A31 cells stimulated with PDGF or HeLa cells stimulated with interferon-α.

    Western Blot Analysis: 0.5-2 μg/mL of this lot detected phosphorylated STAT5A/B in lysates from 3T3/NIH cells stimulated with PDGF. 0.5-2 μg/mL of a previous lot detected phosphorylated STAT5A/B in lysates from 3T3/A31 cells stimulated with PDGF and from HeLa cells stimulated with interferon-a (IFN-a).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-495,Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone 8-5-2

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