merck millipore,默克密理愽
  • merck millipore,默克密理博,324673,EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem

  • merck millipore,默克密理博,324673,EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem

    产品名称：EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem
    产品型号：324673
    The EGFR/ErbB-2 Inhibitor, also referenced under CAS 179248-61-4, controls the biological activity of EGFR/ErbB-2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylati More>>

    merck millipore,默克密理博,324673,EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,324673,EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₃H₂₁N₃O₃179248-61-4
    描述
    概述 A cell-permeable 4-anilino quinazoline compound that acts a potent, reversible, and ATP-competitive inhibitors of EGFR and c-erbB2 (IC50 = 20 nM and 79 nM, respectively), members of the type I growth factor receptor family that is involved in breast cancer development and progression. Shown to effectively inhibit the proliferation (IC50 = ~ 1.2-2.5 µM) of tumor cells overexpressing EGRF or c-erbB-2.
    产品目录编号 324673
    品牌系列 Calbiochem®
    同义词 4557W, 4-(4-Benzyloxyanilino)-6,7-dimethoxyquinazoline
    参考
    参考 Cockerill, S., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1401.
    产品信息
    CAS号 179248-61-4
    具有ATP竞争性 Y
    形式 Off-white solid
    Hill配方 C₂₃H₂₁N₃O₃
    化学配方 C₂₃H₂₁N₃O₃
    Molar Mass 387.4
    可逆 Y
    结构配方图像
    生物信息
    主靶 EGFR
    主靶IC50 20 nM and 79 nM, against EGFR and c-erbB2, respectively
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or MeOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,324673,EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,14-545M,NEK2 Protein, active, 250 µg
下一件merck millipore产品：merck millipore,默克密理博,420142,JNK Inhibitor XI, BI-87G3 - CAS 2207-44-5 - Calbiochem


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