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merck millipore,默克密理博,420142,JNK Inhibitor XI, BI-87G3 - CAS 2207-44-5 - Calbiochem
产品名称：JNK Inhibitor XI, BI-87G3 - CAS 2207-44-5 - Calbiochem
产品型号：420142
The JNK Inhibitor XI, BI-87G3, also referenced under CAS 2207-44-5, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation app More>>
merck millipore,默克密理博,420142,JNK Inhibitor XI, BI-87G3 - CAS 2207-44-5 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₀H₅N₃O₂S₃ 2207-44-5 描述 概述 A cell-permeable benzothiazole compound that inhibits JNK kinase activity (IC50 = 1.8 µM against ATF2 phosphorylation by JNK1) by competing with substrate binding (IC50 = 0.16 µM against pepJIP1 binding to JNK2), while exhibiting much reduced activity toward two other kinases (IC50 >100 µM against p38α and Akt) and two other proteases (IC50 >50 and >100 µM, respectively, against furin and LF). Shown to effectively block cellular c-Jun phosphorylation upon TNF-α stimulation even in HeLa cultures with overexpressed c-Jun substrate (IC50 = 15 µM) and display favorable stability in rat microsome (t1/2 = 70 min) as well as plasma (80% remaining after 60 min) stability assays at 37°C. 产品目录编号 420142 品牌系列 Calbiochem®
同义词 2-(5-Nitrothiazol-2-ylthio)benzo[d]thiazole 参考 参考 De, S.K., et al. 2009. Bioorg. Med. Chem. 17, 2712. 产品信息 CAS号 2207-44-5 形式 Yellow solid Hill配方 C₁₀H₅N₃O₂S₃ 化学配方 C₁₀H₅N₃O₂S₃ Molar Mass 295.4 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 安全信息 R相 R: 20/21/22-36/37/38
Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.S相 S: 22-24/25-36/37/39
Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Harmful
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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