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  • merck millipore,默克密理博,ABE285,Anti-Tristetraprolin Antibody

  • merck millipore,默克密理博,ABE285,Anti-Tristetraprolin Antibody

    产品名称：Anti-Tristetraprolin Antibody
    产品型号：ABE285
    Anti-Tristetraprolin Antibody is an antibody against Tristetraprolin for use in Western Blotting, ICC, Immunoprecipitation, RNA Binding Protein Immunoprecipitation (RIP).

    merck millipore,默克密理博,ABE285,Anti-Tristetraprolin Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABE285,Anti-Tristetraprolin Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABE285
    描述 Anti-Tristetraprolin Antibody
    Alternate Names
    • Zfp-36
    • Tristetraprolin
    • TTP
    • G0/G1 switch regulatory protein 24
    • Growth factor-inducible nuclear protein NUP475
    • Protein TIS11A
    • TIS11
    • Zinc finger protein 36 homolog
    背景信息 Tristetraprolin (TTP, Nup 475, TIS11, G0S24, or ZFP36) is a member of the CCCH tandem zinc finger protein family. It is a nuclear RNA-binding protein that functions as a trans-acting factor. It is involved in post-transcriptional regulation of cytokine genes, most notably Tumor Necrosis Factor alpha (TNF-α). Upon activation by lipopolysaccharides, TTP binds TNF-α mRNA at AU-rich domains in the 3'-untranslated Region (3'-UTR) and induces deadenylation, thereby destabilizing the mRNA and tagging it for degradation. To produce this effect, TTP recruits other trans-acting factors to its C-terminal domain and mRNA-decay enzymes to its N-terminal domain. TTP is deactivated by phosphorylation driven by mitogen-activated protein kinase-activated protein kinase 2 (MK2) and p53. Therefore, TTP/MK2 regulates the biosynthesis of TNF-α and mediates inflammatory responses involving TNF-α. Knockout of TTP in mice produces arthritis, alopecia, dermatitis, among a range of other phenotypes related to overexpression of TNF-α.
    产品信息
    格式 Affinity Purified
    控制
    • A431 cell lysate
    演示 Purified rabbit polyclonal in buffer containing PBS without 0.05% sodium azide.
    应用
    应用 Anti-Tristetraprolin Antibody is an antibody against Tristetraprolin for use in Western Blotting, ICC, Immunoprecipitation, RNA Binding Protein Immunoprecipitation (RIP).
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: A representative lot was used by an independent laboratory to detect Tristetraprolin in human leukocytes. (Brooks, S., et al. (2002). Arthritis and Rheumatism. 46(5):1362–1370.)
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Tristetraprolin.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with Human and Mouse.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_003398
    基因符号
    • TTP
    • ZFP36
    • G0S24
    • RNF162A
    • TIS11A
    纯化方法 Affinity purified
    UniProt编号
    • P26651
    UniProt汇总 FUNCTION: Probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Has been experimentally shown to be able to bind zinc.

    SUBCELLULAR LOCATION: Nucleus.

    INDUCTION: By stimulation with various mitogens.

    SEQUENCE SIMILARITIES: Contains 2 C3H1-type zinc fingers.
    产品使用声明
    质量保证 Evaluated by Western Blot in A431 cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected Tristetraprolin on 10 µg of A431 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABE285,Anti-Tristetraprolin Antibody

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