merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB079-1,Anti-S-100 Protein Antibody, clone 15E2E2

  • merck millipore,默克密理博,MAB079-1,Anti-S-100 Protein Antibody, clone 15E2E2

    产品名称：Anti-S-100 Protein Antibody, clone 15E2E2
    产品型号：MAB079-1
    Anti-S-100 Protein Antibody, clone 15E2E2 is an antibody against S-100 Protein for use in IH, IH(P), IP & WB.

    merck millipore,默克密理博,MAB079-1,Anti-S-100 Protein Antibody, clone 15E2E2

  • 产品介绍
  • merck millipore,默克密理博,MAB079-1,Anti-S-100 Protein Antibody, clone 15E2E2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Fe, H, B, M, R, Ca, RbWB, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB079-1
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-S-100 Protein Antibody, clone 15E2E2
    Alternate Names
    • Calcium Binding Protein A1/B1
    背景信息 S-100 protein is a member of the EF-hand calcium-binding protein superfamily that is widely distributed and conserved in the central nervous system of vertebrates. The protein exists in both heterodimeric and homodimeric forms. The two subunits of S-100 protein are the products of separate genes that are differentially expressed by various cells. The beta subunit is present in all S-100 positive cells and tumors. In contrast, the alpha subunit is detectable only in heart, skeletal muscle and brain. In addition to its calcium binding properties, S-100 protein has a high-affinity binding site for zinc and is involved in the regulation of protein phosphorylation in the brain. The protein apparently plays a role in cell differentiation and growth, cytoskeletal structure and function, and has been implicated in neuropathological diseases.
    产品信息
    格式 Purified
    控制
    • Positive Control Tissue: Melanoma
    演示 Purified mouse monoclonal IgG2aκ in buffer containing PBS, pH 7.6, 1% BSA and 0.09% sodium azide.
    应用
    应用 Anti-S-100 Protein Antibody, clone 15E2E2 is an antibody against S-100 Protein for use in IH, IH(P), IP & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunoprecipitation:
    A previous lot of this antibody was used in IP.

    Visualization of cellular and subcellular localization of S-100 protein using immunohistochemical techniques.

    Immunohistochemistry:
    A 1:100-200 dilution of a previous lot was used for paraffin embedded tissue sections.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Purified bovine S-100 protein
    表位 Recognizes both alpha & beta S100
    克隆 15E2E2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes intact, alpha and beta subunits of bovine, human, and murine S-100 protein, as determined by immunoprecipitation profiles.
    同种型 IgG2aκ
    品种反应性 FelineHumanBovineMouseRatCanineRabbit
    Species Reactivity Note Bovine, human, mouse, and rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_006271.1
    Entrez基因汇总 The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.
    基因符号
    • S100-alpha
    • S100A1
    • S100A
    • S100
    纯化方法 Protein A purfied
    UniProt编号
    • P23297
    UniProt汇总 FUNCTION: SwissProt: P23297 # Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
    SIZE: 94 amino acids; 10546 Da
    SUBUNIT: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain.
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.
    SIMILARITY: SwissProt: P23297 ## Belongs to the S-100 family. & Contains 2 EF-hand domains.
    产品使用声明
    质量保证 Evaluated by Western Blot on PC12 lysates

    Western Blot Analysis:
    1:1000 dilution of this antibody detected S100 on 10 µg of PC12 lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8ºC from date of receipt.
    包装信息
    数量 100 µL
    包装 @ 1 mg/mL concentation

    merck millipore,默克密理博,MAB079-1,Anti-S-100 Protein Antibody, clone 15E2E2

上一件merck millipore产品：merck millipore,默克密理博,05-649,Anti-Chk2 Antibody, clone 7
下一件merck millipore产品：merck millipore,默克密理博,06-1344,Anti-NLRP13 Antibody


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