merck millipore,默克密理博,09-037,Anti-acetyl C/EBPβ Antibody (Lys215, Lys216)

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merck millipore,默克密理博,09-037,Anti-acetyl C/EBPβ Antibody (Lys215, Lys216)
产品名称：Anti-acetyl C/EBPβ Antibody (Lys215, Lys216)
产品型号：09-037
Anti-acetyl C/EBPβ Antibody (Lys215, Lys216) is a Rabbit Polyclonal Antibody for detection of acetyl C/EBP beta (Lys215, Lys216) also known as Nuclear factor NF-IL6 & has been validated in WB.

merck millipore,默克密理博,09-037,Anti-acetyl C/EBPβ Antibody (Lys215, Lys216)

产品介绍

merck millipore,默克密理博,09-037,Anti-acetyl C/EBPβ Antibody (Lys215, Lys216)

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	09-037
品牌系列	Upstate
商名	Upstate
描述	Anti-acetyl C/EBPβ Antibody (Lys215, Lys216)
Alternate Names	CCAAT/enhancer binding protein (C/EBP), beta Nuclear factor NF-IL6 liver-enriched transcriptional activator protein CCAAT/enhancer binding protein (C/EBP)
背景信息	The transcription factor CCAAT/Enhancer Binding Protein beta (C/EBPβ, also known as NFIL6) is a highly conserved B-Zip family member. C/EBPβ regulates multiple genes involved in hepatic function, immune function and adipogenesis, and its functions are generally distinct from those of other C/EBP family members (alpha, gamma, delta, epsilon). C/EBPβ is present in cells as three alternate translation products: two transcription activating forms known as LAP1 and LAP2 (~35 and 32 kDa in rodents, ~43 kDa and 40 kDa in humans) and a truncated inhibitory form known as LIP (~20 kDa) which lacks the N-terminal transcription activation domain. C/EBP β is phosphorylated at multiple sites which are determinants of some of its activities (e.g. activation of c-fos, adipogenesis). A recent report shows that it is acetylated at Lys215/216, and others report that it can be sumoylated. C/EBPβ is also acetylated at Lys39 in the transcription activation domain, and mutation of Lys39 impairs its ability to activate transcription of multiple genes, including several involved in adipogenesis.

产品信息
格式	Affinity Purified
演示	Immunoaffinity purified rabbit IgG in PBS, 0.1% sodium azide, 30% glycerol.

应用
应用	Anti-acetyl C/EBPβ Antibody (Lys215, Lys216) is a Rabbit Polyclonal Antibody for detection of acetyl C/EBP beta (Lys215, Lys216) also known as Nuclear factor NF-IL6 & has been validated in WB.
主要应用	Western Blotting

生物信息
免疫原品种	KLH-conjugated, synthetic peptide containing the sequence (C-AKAKA[acetyl-K][acetyl-K]TVDK), corresponding to a.a. 210-220 of murine C/EBPβ.
表位	a.a. 210-220
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	Recognizes C/EBPβ acetylated on Lys215 and Lys216
品种反应性	MouseHuman
Species Reactivity Note	Human, Mouse
抗体类型	Polyclonal Antibody
Entrez基因编号	1051 NM_009883
Entrez基因汇总	The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.
纯化方法	Immunoaffinity purified
UniProt编号	P17676
UniProt汇总	Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap.

包装信息
数量	100 µg

merck millipore,默克密理博,09-037,Anti-acetyl C/EBPβ Antibody (Lys215, Lys216)

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