• merck millipore,默克密理博,197226,BCRP Inhbitor - Calbiochem
  • merck millipore,默克密理博,197226,BCRP Inhbitor - Calbiochem

    产品名称:BCRP Inhbitor - Calbiochem
    产品型号:197226
    The BCRP Inhbitor controls the biological activity of BCRP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,197226,BCRP Inhbitor - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,197226,BCRP Inhbitor - Calbiochem

    重要规格表

    经验配方
    C₂₂H₁₉N₃O₅
    描述
    概述 A non-tetrahydroisoquinoline BCRP specific inhibitor based on the anthranilic acid scaffold, that displays an IC50 of 1.39 µM in a Hoechst 33343 assay in stably transfected MDCK BCRP cells, which is ˜50-fold more potent than novobiocin (IC50 = 65 µM), and shows no effect towards other ATP binding cassette (ABC) transporters P-gp and MRP1 at up to a concentration of 10 µM. It is shown to be an allosteric inhibitor in enzyme kinetics assays in the presence of BCRP specific substrates pheophorbide A and imitanib, and does not lead to a decrease in cell viability up to a concentration of 10 µM.
    产品目录编号 197226
    品牌系列 Calbiochem®
    同义词 N-(4-(2-hydroxyethyl)phenyl)-2-(4-nitrobenzamido)benzamide
    参考
    参考 Pick, A. et al. 2010. Chem. Med. Chem. 5, 1498.
    Klinkhammer, W., et al. 2009. Bioorg. Med. Chem. 17, 2524.
    产品信息
    形式 Off-white solid
    Hill配方 C₂₂H₁₉N₃O₅
    化学配方 C₂₂H₁₉N₃O₅
    Molar Mass 405.4
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,197226,BCRP Inhbitor - Calbiochem

上一件merck millipore产品:merck millipore,默克密理博,71138,Rosetta-gami™ B(DE3)pLacI Competent Cells - Novagen
下一件merck millipore产品:merck millipore,默克密理博,05-649,Anti-Chk2 Antibody, clone 7



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