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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M ICC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 ABE75 描述 Anti-FOXP3 Antibody, clone 3G3 Alternate Names - immunodeficiency, polyendocrinopathy, enteropathy, X-linked
- forkhead box P3
- immune dysregulation, polyendocrinopathy, enteropathy, X-linked
背景信息 FOXP3 (forkhead box P3) is a member of the FOX protein family and is thought to function as the master regulator in the development and function of regulatory T cells. As a member of the forkhead/winged-helix family of transcriptional regulators FOXP3 is believed to regulate expression through DNA binding. Mutations and deletions in the sequence encoding for FOXP3 expression lead to an inability to express FOXP3, causing an inability to regulate T cell development and leading to fatal autoimmune diseases such as IPEX and XLAAD. Conversely, other studies have shown high and wide expression of FOXP3 in several cancer cell lines and tumors, indicating that FOXP3 is involved in preventing immunity against malignant tumors. 产品信息 格式 Serum 控制 - HEK293 cell lysate
演示 Rabbit polyclonal serum containing 0.5% sodium azide. 应用 应用 Use Anti-FOXP3 Antibody, clone 3G3 (Rabbit Polyclonal Antibody) validated in WB, ICC to detect FOXP3 also known as forkhead box P3. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected FOXP3 in A431 cells. 生物信息 免疫原品种 Linear peptide corresponding to human FOXP3. 宿主 Rabbit 同种型 IgG 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with human, mouse, and rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_054728
Entrez基因汇总 The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]. 基因符号 - scurfin
- FOXP3
- AIID
- DIETER
- IPEX
- JM2
- PIDX
- SCURFIN
- Scurfin
- XPID
纯化方法 Unpurified UniProt编号 - Q9BZS1
UniProt汇总 FUNCTION: Probable transcription factor. Plays a critical role in the control of immune response.
SUBCELLULAR LOCATION: Nucleus (Potential).
INVOLVEMENT IN DISEASE: Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.
SEQUENCE SIMILARITIES: Contains 1 C2H2-type zinc finger.
Contains 1 fork-head DNA-binding domain.产品使用声明 质量保证 Evaluated by Western Blot in HEK293 cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected FOXP3 on 10 µg of HEK293 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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