merck millipore,默克密理愽
  • merck millipore,默克密理博,FCMAB140P,Milli-Mark™ Anti-phospho-Bcl-2 (Ser70) -PE Antibody, clone 69-10C-2-10C-18

  • merck millipore,默克密理博,FCMAB140P,Milli-Mark™ Anti-phospho-Bcl-2 (Ser70) -PE Antibody, clone 69-10C-2-10C-18

    产品名称：Milli-Mark™ Anti-phospho-Bcl-2 (Ser70) -PE Antibody, clone 69-10C-2-10C-18
    产品型号：FCMAB140P
    Detect phospho-Bcl-2 (Ser70) using this Milli-Mark Anti-phospho-Bcl-2 (Ser70) -PE Antibody, clone 69-10C-2-10C-18 validated for use in FC.

    merck millipore,默克密理博,FCMAB140P,Milli-Mark™ Anti-phospho-Bcl-2 (Ser70) -PE Antibody, clone 69-10C-2-10C-18

  • 产品介绍
  • merck millipore,默克密理博,FCMAB140P,Milli-Mark™ Anti-phospho-Bcl-2 (Ser70) -PE Antibody, clone 69-10C-2-10C-18

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCRbPhycoerythrinPolyclonal Antibody
    描述
    产品目录编号 FCMAB140P
    商名
    • Milli-Mark
    描述 Milli-Mark™ Anti-phospho-Bcl-2 (Ser70) -PE Antibody, clone 69-10C-2-10C-18
    Alternate Names
    • B-cell CLL/lymphoma 2 <br />B-cell lymphoma protein 2
    背景信息 The Bcl name is derived from B-cell chronic lymphocytic leukemia, and was given to genes involved in that disease. Members of the Bcl-2 family share homologous domains (BH) through which they are able to homo- and hetero-dimerize. Bcl-2 plays an important role in cytochrome c release from the mitochondria; it also binds Apaf1, inhibiting Apaf-1 association with caspase-9. Bcl-2 overexpression in indicated in a number of human cancers, including melanoma, breast, prostate, and lung, and it correlates with resistance to cancer treatment (presumably due to decreased apoptosis). Bcl-2 has also been implicated in schizophrenia and autoimmune disorders. Bcl-2 phosphorylated at Ser-70 plays a critial role in the translocation of Bax from the cytosol to the mitochondria, and this may regulate NO-induced neuronal apoptosis. The molecular mechanism of Bcl-2 phosphorylation and its relationship to Bax is largely unknown.
    产品信息
    格式 Phycoerythrin
    控制
    • Jurkat cells.
    演示 Purified rabbit monoclonal IgG conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 Detect phospho-Bcl-2 (Ser70) using this Milli-Mark Anti-phospho-Bcl-2 (Ser70) -PE Antibody, clone 69-10C-2-10C-18 validated for use in FC.
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Bcl-2 phosphorylated at Ser70.
    表位 Ser70
    克隆 69-10C-2-10C-18
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes phosphorylated Bcl-2 at Ser70.
    同种型 IgG
    品种反应性 Human
    Species Reactivity Note Tested and passed on Human.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_000624.2
    Entrez基因汇总 This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq]
    基因符号
    • Bcl-2
    • BCL2
    纯化方法 Protein A purfied
    UniProt编号
    • P10415
    UniProt汇总 FUNCTION: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

    SUBUNIT STRUCTURE: Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity By similarity. Also interacts with APAF1, RAF-1, TP53BP2, BBC3, BCL2L1, MRPL41 and BNIPL. Binding to FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets.

    SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

    TISSUE SPECIFICTY: Expressed in a variety of tissues.

    DOMAIN: The BH4 motif is required for anti-apoptotic activity and for interaction with RAF-1.

    PTM: Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Dephosphorylated by protein phosphatase 2A (PP2A) By similarity.

    Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further caspase activity. INVOLVEMENT IN DISEASE: A chromosomal aberration involving BCL2 may be a cause of follicular lymphoma (FL) [MIM:151430]; also known as type II chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.

    SEQUENCE SIMLARITIES: Belongs to the Bcl-2 family.
    产品使用声明
    质量保证 Evaluated by flow cytometry using Jurkat cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 tests

    merck millipore,默克密理博,FCMAB140P,Milli-Mark™ Anti-phospho-Bcl-2 (Ser70) -PE Antibody, clone 69-10C-2-10C-18

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下一件merck millipore产品：merck millipore,默克密理博,2510-OP,OmniPur BCIP


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