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merck millipore,默克密理博,553015,Raf Kinase Inhibitor V - CAS 918505-84-7 - Calbiochem
产品名称：Raf Kinase Inhibitor V - CAS 918505-84-7 - Calbiochem
产品型号：553015
The Raf Kinase Inhibitor V, also referenced under CAS 918505-84-7, controls the biological activity of Raf Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylati More>>
merck millipore,默克密理博,553015,Raf Kinase Inhibitor V - CAS 918505-84-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₇H₁₄ClF₂N₃O₃S 918505-84-7 描述 概述 A cell-permeable azaindole compound that interacts with Raf via both the ATP-binding site and a "Raf-selective pocket" that exhibits conformation-dependent inhibitor-binding modes and accounts for the compound's preferential binding and inhibitory activity toward the active Raf mutants (IC50 = 6.7, 13, 130, 160, and >1,300 nM against C-Raf-1Y340D/Y341D, B-RafV600E, BRK, WT B-Raf, and 64 other kinases, respectively). Shown to inhibit the proliferation and cellular Erk phosphorylation much more potently in B-RafV600E-bearing than WT B-Raf-bearing cancer cell lines in vitro and effectively suppress COLO205-derived tumor growth in mice in vivo (near complete regression during the 1-wk treatment period; 20 mg/kg, daily, p.o.). 产品目录编号 553015 品牌系列 Calbiochem®
同义词 Propane-1-sulfonic acid-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl)-amide, PLX4720 参考 参考 Tsai, J., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 3041. 产品信息 CAS号 918505-84-7 形式 Orange-yellow solid Hill配方 C₁₇H₁₄ClF₂N₃O₃S 化学配方 C₁₇H₁₄ClF₂N₃O₃S Molar Mass 413.8 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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