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merck millipore,默克密理博,FCMAB206F,Milli-Mark™ Anti-CD69- FITC Antibody, clone FN50
产品名称：Milli-Mark™ Anti-CD69- FITC Antibody, clone FN50
产品型号：FCMAB206F
Milli-Mark Anti-CD69-FITC Antibody, clone FN50 detects level of CD69 & has been published & validated for use in FC.
merck millipore,默克密理博,FCMAB206F,Milli-Mark™ Anti-CD69- FITC Antibody, clone FN50
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC M FITC Monoclonal Antibody 描述 产品目录编号 FCMAB206F 商名 - Milli-Mark
描述 Milli-Mark™ Anti-CD69- FITC Antibody, clone FN50 Alternate Names - C-type lectin domain family 2 member C
- Early activation antigen CD69
- Early T-cell activation antigen p60
- GP32/28
- Leukocyte surface antigen Leu-23
- MLR-3
- EA1
- BL-AC/P26
- Activation inducer molecule (AIM)
背景信息 CD69 is a phosphorylated disulphide-linked dimmer composed of two chains of 27 kDa and 33 kDa, and also known as activation inducer molecule (AIM). CD69 is the earliest inducible surface antigen expressed on lymphocytes after T and B cell activation. CD69 is absent from resting lymphocytes (Sanchez-Madrid, 1995). Other cells, including epidermal Langerhans cells, natural killer (NK) cells, eosinophils, neutrophils, and platelets may also express CD69 (Poggi, 2002). In vitro studies have demonstrated a transient expression of CD69 on activated T cells. After activation, surface expression can be detected within 2-4 hours, reaching a maximum after 18-24 hours followed by a gradual decrease (Hara, 1986). CD69 is thus detectable prior to other activation antigens like CD25 and CD71. CD69 is believed to be involved in signal transduction, since cross-linking with anti-CD69 induces activation (Testi, 1989).
Anti-CD69 may be useful for T cell activation studies when used in combination with anti-CD4, anti-CD8, and anti-CD3.产品信息 格式 FITC 控制 - Jurkat cells
演示 Purified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2. 应用 应用 Milli-Mark Anti-CD69-FITC Antibody, clone FN50 detects level of CD69 & has been published & validated for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Activated B cells, isolated from human peripheral blood 克隆 FN50 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Tested and passed on Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001772
Entrez基因汇总 This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. Alternative splicing results in multiple transcript variants. 纯化方法 Protein A Purified UniProt编号 - Q07108
UniProt汇总 Function: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
Subunit structure: Homodimer; disulfide-linked.
Subcellular location: Membrane; Single-pass type II membrane protein.
Tissue specificity: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets.
Developmental stage: Earliest inducible cell surface glycoprotein acquired during lymphoid activation.
Induction: By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells. Post-translational modification: Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes.
Sequence similarities: Contains 1 C-type lectin domain.
产品使用声明 质量保证 Evaluated by flow cytometry using jurkat cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 tests
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