merck millipore,默克密理愽
  • merck millipore,默克密理博,05-362,Anti-Cyclin D1/2 Antibody, clone 5D4

  • merck millipore,默克密理博,05-362,Anti-Cyclin D1/2 Antibody, clone 5D4

    产品名称：Anti-Cyclin D1/2 Antibody, clone 5D4
    产品型号：05-362
    Anti-Cyclin D1/2 Antibody, clone 5D4 is a high quality Mouse Monoclonal Antibody for the detection of Cyclin D1/2 & has been validated in ICC, IP & WB.

    merck millipore,默克密理博,05-362,Anti-Cyclin D1/2 Antibody, clone 5D4

  • 产品介绍
  • merck millipore,默克密理博,05-362,Anti-Cyclin D1/2 Antibody, clone 5D4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, Ht, MWB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-362
    Replaces 04-1151
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Cyclin D1/2 Antibody, clone 5D4
    背景信息 During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by acting as regulatory subunits of the Cdks. Early in the G1 phase of the cell cycle, cyclin D1 induction is followed by cyclin E induction. This sequential progression is marked early on in G1 by the activation of Cdk4 and in mid to late G1 by the activation of Cdk2 and the hyperphosphorylation of pRB. The final transition into S phase is thought to be dependent on the increased expression and association of cyclin E and Cdk2. Cyclin D2 is also a G1 cyclin required for G1 phase progression and is a strong candidate for a proto oncogene. Cyclin D2 can phosphorylate pRB when associated with cdk 4 and / or cdk 6.
    产品信息
    格式 Purified
    控制
    • Positive Control Included: Non-Stim A431 Cell Lysate (12-301)
    演示 Protein A Purified immunoglobulin in Protein G Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
    应用
    应用 Anti-Cyclin D1/2 Antibody, clone 5D4 is a high quality Mouse Monoclonal Antibody for the detection of Cyclin D1/2 & has been validated in ICC, IP & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    生物信息
    免疫原品种 Recombinant human cyclin D1
    克隆 5D4
    宿主 Mouse
    特异性 Recognizes p36 cyclin D1 and p34 cyclin D2; no cross-reactivity with cyclin A, B or D3.
    同种型 IgG2a
    品种反应性 RatHumanHamsterMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_053056, NM_001759
    Entrez基因汇总 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
    基因符号
    • BCL1
    • CCND1
    • D11S287E
    • U21B31
    • PRAD1
    纯化方法 Protein A purfied
    UniProt编号
    • P24385
    UniProt汇总 FUNCTION: SwissProt: P24385 # Essential for the control of the cell cycle at the G1/S (start) transition.
    SIZE: 295 amino acids; 33729 Da
    SUBUNIT: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
    DISEASE: SwissProt: P24385 # A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle. & A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM:168461]. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer. & A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM:254500]. Translocation t(11;14)(q13;q32) with the IgH locus.
    SIMILARITY: SwissProt: P24385 ## Belongs to the cyclin family. Cyclin D subfamily.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysate from human A431 cells
    销售限制 This product is not available for sale in Japan.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-362,Anti-Cyclin D1/2 Antibody, clone 5D4

上一件merck millipore产品：merck millipore,默克密理博,MABN649,Anti-Potassium Channel KChIP1 Antibody
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